Ankyrin-1 Antibody (H-4): sc-374240

Ankyrin-1 Antibody (H-4) is a mouse monoclonal IgG2a antibody that detects Ankyrin-1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Ankyrin-1 plays a crucial role in maintaining the structural integrity of cells by linking integral membrane proteins to the cytoskeleton, which is essential for cellular stability and function. Ankyrin-1 is predominantly located in the plasma membrane of erythrocytes, cardiac and skeletal muscle, and neurons, where Ankyrin-1 facilitates the organization of membrane domains and the anchoring of cytoskeletal components. The proper localization of Ankyrin-1 is vital for the maintenance of cell shape and the regulation of ion channels, which are critical for muscle contraction and neuronal signaling. Additionally, Ankyrin-1 exists in multiple isoforms, each contributing to diverse functional roles in different tissues. Notably, defects in Ankyrin-1 have been implicated in hereditary spherocytosis, a condition characterized by the destruction of red blood cells, highlighting the importance of Ankyrin-1 in both health and disease. Anti-Ankyrin-1 antibody (H-4) provides reliable detection and characterization of Ankyrin-1, making anti-Ankyrin-1 antibody (H-4) an invaluable tool for researchers studying cytoskeletal dynamics and membrane interactions in various biological contexts.

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Ankyrin-1 Antibody (H-4) References:

1. Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.  |  Baraldi, PG., et al. 2010. J Med Chem. 53: 5085-107. PMID: 20356305
2. Modulation of transient receptor vanilloid 1 activity by transient receptor potential ankyrin 1.  |  Spahn, V., et al. 2014. Mol Pharmacol. 85: 335-44. PMID: 24275229
3. Full-Length Anion Exchanger 1 Structure and Interactions with Ankyrin-1 Determined by Zero Length Crosslinking of Erythrocyte Membranes.  |  Rivera-Santiago, R., et al. 2017. Structure. 25: 132-145. PMID: 27989623
4. Transient Receptor Potential Ankyrin 1 Contributes to Lysophosphatidylcholine-Induced Intracellular Calcium Regulation and THP-1-Derived Macrophage Activation.  |  Tian, C., et al. 2020. J Membr Biol. 253: 43-55. PMID: 31820013
5. Transient receptor potential ankyrin-1 causes rapid bronchodilation via nonepithelial PGE2.  |  Marsh, BJ., et al. 2020. Am J Physiol Lung Cell Mol Physiol. 318: L943-L952. PMID: 32233794
6. Inhibition of transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 by mosquito and mouse saliva.  |  Derouiche, S., et al. 2022. Pain. 163: 299-307. PMID: 33990108
7. The role of transient receptor potential ankyrin 1 in age-related endothelial dysfunction.  |  Yang, Y., et al. 2021. Exp Gerontol. 154: 111517. PMID: 34419618
8. Upregulation of transient receptor potential ankyrin 1 (TRPA1) but not transient receptor potential vanilloid 1 (TRPV1) during primary tooth carious progression.  |  Wichaidit, A., et al. 2023. J Oral Biosci. 65: 24-30. PMID: 36587734
9. Transient Receptor Potential Ankyrin 1 in Taste Nerve Contributes to the Sense of Sweet Taste in Mice.  |  Matsumoto, K., et al. 2023. Biol Pharm Bull. 46: 939-945. PMID: 37394645
10. Transient Receptor Potential Ankyrin 1 Ion Channel Is Expressed in Osteosarcoma and Its Activation Reduces Viability.  |  Hudhud, L., et al. 2024. Int J Mol Sci. 25: PMID: 38612571

The preferred Ankyrin-1 antibody is Ankyrin-1 Antibody (8C3): sc-12733.