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Ac-Histone H4 [Ser 1/Lys 5/Lys 8/Lys 12] Antibody (G-2): sc-393472
- Ac-Histone H4 [Ser 1/Lys 5/Lys 8/Lys 12] Antibody (G-2) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3-22 acetylated Serine 1 and Lysine 5, 8 and 12 of Histone H4 of human origin
- recommended for detection of Serine 1, Lysine 5, Lysine 8 and Lysine 12 acetylated Histone H4 of broad species and origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Ac-Histone H4 [Ser 1/Lys 5/Lys 8/Lys 12] Antibody (G-2) for WB applications. These reagents are now offered in bundles with Ac-Histone H4 [Ser 1/Lys 5/Lys 8/Lys 12] Antibody (G-2) (see ordering information below).
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SEE ALSO...
Ac-Histone H4 [Ser 1/Lys 5/Lys 8/Lys 12] Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects Histone H4 across multiple species through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Histone H4 antibody (G-2) specifically recognizes acetylated forms of Histone H4, which plays a crucial role in gene expression regulation and chromatin dynamics. Histone H4 is primarily located in the nucleus, where this protein forms part of the nucleosome structure, wrapping DNA to create a compact chromatin architecture. Such structural organization protects DNA and regulates access to genetic information, influencing transcriptional activity. Acetylation of Histone H4 at specific lysine residues, such as Lys 5 and Lys 8, associates with transcriptional activation by creating a more relaxed chromatin state, allowing transcription factors and regulatory proteins to access DNA. Understanding Histone H4 modifications and interactions helps elucidate gene regulation mechanisms and epigenetic landscapes, with significant implications for developmental biology and disease states, including cancer.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ac-Histone H4 [Ser 1/Lys 5/Lys 8/Lys 12] Antibody (G-2) | sc-393472 | 200 µg/ml | $322.00 | |||
Ac-Histone H4 [Ser 1/Lys 5/Lys 8/Lys 12] Antibody (G-2): m-IgG Fc BP-HRP Bundle | sc-538226 | 200 µg Ab; 10 µg BP | $361.00 | |||
Ac-Histone H4 [Ser 1/Lys 5/Lys 8/Lys 12] Antibody (G-2): m-IgGκ BP-HRP Bundle | sc-535795 | 200 µg Ab; 40 µg BP | $361.00 | |||
Ac-Histone H4 [Ser 1/Lys 5/Lys 8/Lys 12] Antibody (G-2): m-IgG1 BP-HRP Bundle | sc-545588 | 200 µg Ab; 20 µg BP | $361.00 | |||
Ac-Histone H4 [Ser 1/Lys 5/Lys 8/Lys 12] (G-2) Neutralizing Peptide | sc-393472 P | 100 µg/0.5 ml | $69.00 |