SLIT-ROBO Rho GTPase activating protein (SRGAP)阻害剤

The SLIT-ROBO Rho GTPase activating protein (SRGAP) signaling pathway plays a crucial role in various cellular processes. It is primarily involved in axon guidance and neuronal migration, essential for proper brain development. This signaling pathway is activated when SLIT proteins bind to ROBO receptors, leading to the activation of SRGAPs. Upon activation, SRGAPs modulate the activity of Rho GTPases, which are key regulators of the actin cytoskeleton. This regulation influences cell shape, migration, and neuronal connections, highlighting the pathway's importance in neurodevelopment and potentially in neurodevelopmental disorders.

Targeting the SLIT-ROBO Rho GTPase activating protein (SRGAP) for disruption or inhibition involves interfering with a critical pathway in neuronal development and cell migration. This can be achieved by targeting the interaction between SLIT ligands and ROBO receptors, thereby the activation of SRGAP proteins. Alternatively, inhibition can focus on the downstream effectors of SRGAP, particularly the Rho family of GTPases, to disrupt the actin cytoskeleton regulation