Pirh2 Antibody (E-11): sc-166901

Pirh2 Antibody (E-11) is a mouse monoclonal IgG1 antibody that detects Pirh2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Pirh2, also known as Androgen receptor N-terminal-interacting protein (ARNIP), ZN363, or CHIMP, plays a critical role in regulating the p53 tumor suppressor pathway by exhibiting p53-induced ubiquitin-protein ligase activity, which promotes p53 degradation. This interaction is significant because p53 is a key regulator of the cell cycle and apoptosis, and p53 loss of function is closely associated with various malignancies. The gene encoding Pirh2 is located on chromosome 4q21.1, and Pirh2 expression is intricately regulated by p53, creating a feedback loop that maintains cellular homeostasis. Notably, Pirh2 expression decreases p53 levels, while reduced Pirh2 expression leads to increased p53 levels, highlighting Pirh2′s role as a negative regulator of p53 function alongside MDM2. Pirh2′s ability to modulate p53 levels underscores Pirh2′s potential as a target for therapeutic intervention in cancer, making anti-Pirh2 antibody (E-11) an invaluable tool for researchers studying tumor biology and oncogenesis mechanisms.

The preferred Pirh2 antibody is Pirh2 Antibody (D-12): sc-374505.