PDZK1 Antibody (42): sc-136028
- PDZK1 Antibody (42) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 431-523 of PDZK1 of rat origin
- recommended for detection of PDZK1 of mouse and rat origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PDZK1 Antibody (42). This work is in progress.
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PDZK1 Antibody (42) is a mouse monoclonal IgG1 antibody that detects PDZK1 in mouse and rat samples through applications such as western blotting (WB) and immunoprecipitation (IP). PDZK1 contains four PDZ domains, which are essential for functioning as a scaffolding protein that organizes various signaling complexes at the plasma membrane of epithelial cells. This localization enables anti-PDZK1 antibody (42) to interact with multiple ion channels and receptors simultaneously, facilitating the coordination of cellular signaling pathways. PDZK1′s role as an adaptor between different cell surface receptors is vital for maintaining cellular homeostasis and regulating ion transport, which is critical for numerous physiological processes. PDZK1 (42) monoclonal antibody has revealed increased expression in human carcinomas of epithelial origin, suggesting involvement in tumor progression and potential contribution to multidrug resistance in cancer therapy. By studying PDZK1, researchers may uncover new strategies to combat chemoresistance in cancer cells, making PDZK1 (42) antibody an invaluable tool for studies focused on cancer biology and therapeutic resistance.
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PDZK1 Antibody (42) References:
- Regulation of SR-BI-mediated high-density lipoprotein metabolism by the tissue-specific adaptor protein PDZK1. | Yesilaltay, A., et al. 2005. Curr Opin Lipidol. 16: 147-52. PMID: 15767854
- Role of the adaptor protein PDZK1 in controlling the HDL receptor SR-BI. | Kocher, O. and Krieger, M. 2009. Curr Opin Lipidol. 20: 236-41. PMID: 19421056
- PDZK1 regulates breast cancer resistance protein in small intestine. | Shimizu, T., et al. 2011. Drug Metab Dispos. 39: 2148-54. PMID: 21816982
- PDZK1 upregulation in estrogen-related hyperpigmentation in melasma. | Kim, NH., et al. 2012. J Invest Dermatol. 132: 2622-31. PMID: 22696060
- Loss of PDZK1 expression activates PI3K/AKT signaling via PTEN phosphorylation in gastric cancer. | Zhao, C., et al. 2019. Cancer Lett. 453: 107-121. PMID: 30930234
- PDZK1 Interacting Protein 1 Promotes the Progression of Papillary Thyroid Cancer. | Wang, K., et al. 2022. J Clin Endocrinol Metab. 107: 2449-2461. PMID: 35727731
- Promoter hypomethylated PDZK1 acts as a tumorigenic gene in glioma by interacting with AKT1. | Ren, X., et al. 2024. Aging (Albany NY). 16: 7174-7187. PMID: 38669103
- PDZK1 is correlated with DCE-MRI perfusion parameters in high-grade glioma. | Zhang, Y., et al. 2024. Clinics (Sao Paulo). 79: 100367. PMID: 38692010
- PDZK1 confers sensitivity to sunitinib in clear cell renal cell carcinoma by suppressing the PDGFR-β pathway. | Wang, H., et al. 2024. Br J Cancer. 131: 347-360. PMID: 38822145
- PDZK1 downregulation linked to mitochondrial dysfunction in OA. | Papatriantafyllou, M. 2024. Nat Rev Rheumatol. 20: 597. PMID: 39164423
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PDZK1 Antibody (42) | sc-136028 | 50 µg/0.5 ml | $322.00 |