patched/PTCH1 Antibody (E-7): sc-518046

Patched Antibody (E-7) is a mouse monoclonal IgG1 antibody that detects patched protein in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Patched, a critical component of the hedgehog signaling pathway, plays a vital role in regulating cell growth and differentiation during embryonic development. Anti-patched antibody (E-7) acts as a receptor for hedgehog ligands, thereby modulating the activity of downstream signaling pathways that influence cellular processes. Patched (E-7) monoclonal antibody maintains proper cellular communication; when patched is mutated or dysregulated, uncontrolled cell proliferation can occur and contribute to the development of various cancers, including basal cell carcinoma, which is the most prevalent form of skin cancer in the United States, affecting approximately 750,000 individuals annually. Additionally, patched interacts with other proteins in the hedgehog pathway, such as Sonic hedgehog and patched 2, further emphasizing patched′s role in cellular signaling and development. Anti-patched antibody (E-7) serves as an essential tool for researchers investigating the complexities of the hedgehog signaling pathway and its implications in cancer biology.

The preferred patched/PTCH1 antibody is patched/PTCH1 Antibody (H-10): sc-518102.