p-Stat3 Antibody (pS727.25): sc-293059
- p-Stat3 Antibody (pS727.25) is a mouse monoclonal IgG1 κ, cited in 10 publications, provided at 200 µg/ml
- raised against a short amino acid sequence containing phosphorylated Ser 727 of Stat3 of human origin
- recommended for detection of Ser 727 phosphorylated Stat3 of human and rat origin of human and rat origin by WB, IP and IF; non cross-reactive with Ser 727 phosphorylated Stat3 of mouse origin
- TransCruz reagent for Gel Supershift and ChIP applications (sc-293059 X, 200 µg/0.1 ml)
- m-IgG1 BP-HRP is the preferred secondary detection reagent for p-Stat3 Antibody (pS727.25) for WB applications. This reagent is now offered in a bundle with p-Stat3 Antibody (pS727.25) (see ordering information below).
p-Stat3 Antibody (pS727.25) is a mouse monoclonal IgG1 antibody that detects phosphorylated Stat3 in human and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p-Stat3 monoclonal antibody (pS727.25) recognizes the phosphorylated form of Stat3 at serine 727, a critical modification that plays a significant role in the regulation of gene expression and cellular responses to various stimuli, including cytokines and growth factors. The phosphorylation of Stat3 at this site is essential for its full transcriptional activity, influencing processes such as cell proliferation, survival, and differentiation. Stat3 is predominantly located in the cytoplasm but translocates to the nucleus upon activation, where Stat3 binds to specific DNA sequences to modulate the expression of target genes involved in immune responses and oncogenesis. The ability of Stat3 to interact with other signaling pathways, including those mediated by Janus kinases (JAKs) and various cytokines, underscores Stat3′s importance in both normal physiological processes and pathological conditions, such as cancer and autoimmune diseases. p-Stat3 monoclonal antibody (pS727.25) is an invaluable tool for researchers investigating the intricate signaling networks that govern cell behavior and the implications of Stat3 activation in disease states.
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p-Stat3 Antibody (pS727.25) References:
- p-STAT3 in luminal breast cancer: Integrated RNA-protein pooled analysis and results from the BIG 2-98 phase III trial. | Sonnenblick, A., et al. 2018. Int J Oncol. 52: 424-432. PMID: 29207087
- G6PD promotes renal cell carcinoma proliferation through positive feedback regulation of p-STAT3. | Zhang, Q., et al. 2017. Oncotarget. 8: 109043-109060. PMID: 29312589
- Curcumin inhibits the proliferation and invasion of MG-63 cells through inactivation of the p-JAK2/p-STAT3 pathway. | Sun, Y., et al. 2019. Onco Targets Ther. 12: 2011-2021. PMID: 30936718
- Alcohol's Dysregulation of Maternal-Fetal IL-6 and p-STAT3 Is a Function of Maternal Iron Status. | Saini, N., et al. 2019. Alcohol Clin Exp Res. 43: 2332-2343. PMID: 31524964
- Gestational exposure to valproic acid upregulates total Stat3 protein expression while downregulating phosphorylated Stat3 in CD-1 mouse embryos with neural tube defects. | Shafique, S. and Winn, LM. 2020. Birth Defects Res. 112: 555-568. PMID: 32134217
- P-STAT3 and IL-17 in tumor tissues enhances the prognostic value of CEA and CA125 in patients with lung adenocarcinoma. | Chen, XK., et al. 2020. Biomed Pharmacother. 125: 109871. PMID: 32187953
- SHP1 Decreases Level of P-STAT3 (Ser727) and Inhibits Proliferation and Migration of Pancreatic Cancer Cells. | Zhang, M., et al. 2021. J Environ Pathol Toxicol Oncol. 40: 17-27. PMID: 33639070
- High Dimensional Analyses of Circulating Immune Cells in Psoriatic Arthritis Detects Elevated Phosphorylated STAT3. | Macaubas, C., et al. 2021. Front Immunol. 12: 758418. PMID: 35087513
- BCAM Deficiency May Contribute to Preeclampsia by Suppressing the PIK3R6/p-STAT3 Signaling. | Liu, M., et al. 2022. Hypertension. 79: 2830-2842. PMID: 36252138
- The alcohol extracts of Sceptridium ternatum (Thunb.) Lyon exert anti-pulmonary fibrosis effect through targeting SETDB1/STAT3/p-STAT3 signaling. | Zou, X., et al. 2023. J Ethnopharmacol. 313: 116520. PMID: 37120058
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Stat3 Antibody (pS727.25) | sc-293059 | 200 µg/ml | $322.00 | |||
p-Stat3 Antibody (pS727.25): m-IgG1 BP-HRP Bundle | sc-550932 | 200 µg Ab; 20 µg BP | $361.00 | |||
p-Stat3 Antibody (pS727.25) X | sc-293059 X | 200 µg/0.1 ml | $322.00 |