p-mTOR Antibody (296.Ser 2481): sc-293132

p-mTOR Antibody (296.Ser 2481) is a mouse monoclonal IgG2b kappa light chain antibody that detects phosphorylated mTOR at Ser 2481 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). p-mTOR (296.Ser 2481) antibody is available in both conjugated and non-conjugated forms, providing flexibility for different experimental needs. The mechanistic target of rapamycin (mTOR) plays a crucial role in cellular growth and metabolism, acting as a central regulator of cell proliferation and survival by integrating signals from nutrients, growth factors, and cellular energy status. This regulation is vital for maintaining cellular homeostasis and responding to environmental changes, making mTOR a key player in various physiological processes, including autophagy, protein synthesis, and cell cycle progression. mTOR is involved in several diseases, including cancer and metabolic disorders, where dysregulation can lead to uncontrolled cell growth and proliferation. The phosphorylation of mTOR at Ser 2481 is particularly significant as this modification occurs under translationally repressive conditions, highlighting mTOR′s role in cellular response to stress and nutrient availability. Understanding mTOR function and regulation is essential for developing targeted therapies in diseases associated with mTOR dysfunction.

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p-mTOR Antibody (296.Ser 2481) References:

1. Prognostic value of phosphorylated mTOR/RPS6KB1 in non- small cell lung cancer.  |  Zhang, Y., et al. 2013. Asian Pac J Cancer Prev. 14: 3725-8. PMID: 23886172
2. Expression of phosphorylated-mTOR during the development of prostate cancer.  |  Sutherland, SI., et al. 2014. Prostate. 74: 1231-9. PMID: 25043667
3. Profiling of the fetal and adult rat liver transcriptome and translatome reveals discordant regulation by the mechanistic target of rapamycin (mTOR).  |  Boylan, JM., et al. 2015. Am J Physiol Regul Integr Comp Physiol. 309: R22-35. PMID: 25924882
4. pmTOR is a marker of aggressiveness in papillary thyroid carcinomas.  |  Tavares, C., et al. 2016. Surgery. 160: 1582-1590. PMID: 27574774
5. Clinicopathological and prognostic significance of mTOR and phosphorylated mTOR expression in patients with esophageal squamous cell carcinoma: a systematic review and meta-analysis.  |  Li, S., et al. 2016. BMC Cancer. 16: 877. PMID: 27835987
6. Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas.  |  Bi, C., et al. 2017. Haematologica. 102: 755-764. PMID: 28104700
7. P-mTOR Expression and Implication in Breast Carcinoma: A Systematic Review and Meta-Analysis.  |  Ding, XF., et al. 2017. PLoS One. 12: e0170302. PMID: 28114374
8. MicroRNA-496 and Mechanistic Target of Rapamycin Expression are Associated with Type 2 Diabetes Mellitus and Obesity in Elderly People.  |  Rubie, C., et al. 2019. Ann Nutr Metab. 74: 279-286. PMID: 30939476
9. Myeloid-derived suppressor cells (MDSCs) and mechanistic target of rapamycin (mTOR) signaling pathway interact through inducible nitric oxide synthase (iNOS) and nitric oxide (NO) in asthma.  |  Zhang, Y., et al. 2019. Am J Transl Res. 11: 6170-6184. PMID: 31632585
10. Phosphorylated mTOR expression as a predictor of survival after liver resection for colorectal liver metastases.  |  Konishi, T., et al. 2021. J Surg Oncol. 124: 598-606. PMID: 34061356

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-mTOR Antibody (296.Ser 2481) has 37 citations in a variety of scientific publications.

Primary antibodies like Anti-p-mTOR Antibody (296.Ser 2481) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-mTOR Antibody (296.Ser 2481) Specifications

Alternate Product Name: mTOR

Product Clone Name: 296.Ser 2481

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: Ser 2481

Epitope Target: mTOR

Epitope Species: human

Product Reactivity/Detection: Ser 2481 phosphorylated mTOR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 37 citations in various scientific publications

Available Conjugates/Forms for p-mTOR Antibody (296.Ser 2481): AC: Agarose, HRP: Horseradish Peroxidase

The preferred p-mTOR antibody is p-mTOR Antibody (59.Ser 2448): sc-293133.