NFATc4 Antibody (A-2): sc-271127
- NFATc4 Antibody (A-2) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 125-198 of NFATc4 of human origin
- recommended for detection of NFATc4 of human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-271127 X, 200 µg/0.1 ml)
- See NFATc4 (B-2): sc-271597 for NFATc4 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP is the preferred secondary detection reagent for NFATc4 Antibody (A-2) for WB applications. This reagent is now offered in a bundle with NFATc4 Antibody (A-2) (see ordering information below).
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NFATc4 Antibody (A-2) is a mouse monoclonal IgG2b antibody that detects NFATc4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NFATc4, or nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 4, is a crucial transcription factor that plays a significant role in regulating cytokine gene expression, particularly in T cells, where NFATc4 is essential for the inducible expression of cytokines like IL-2 and IL-4. NFATc4 is located primarily in the cytoplasm and translocates to the nucleus upon T cell receptor stimulation, a process that is vital for the activation of immune responses. This translocation is not only critical for T cell function but also influences various physiological processes, including cardiac hypertrophy and adipocyte differentiation. Additionally, NFATc4 is subject to post-translational modifications, such as phosphorylation by p38 MAP kinase, which modulates NFATc4 activity and stability, further underscoring NFATc4′s importance in cellular signaling pathways. Anti-NFATc4 antibody (A-2) is an invaluable tool for researchers studying immune responses and related signaling mechanisms in human cells.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NFATc4 Antibody (A-2) References:
- Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. | Yang, TT., et al. 2002. Mol Cell Biol. 22: 3892-904. PMID: 11997522
- Immunolocalization of NFATc4 in the adult mouse brain. | Bradley, KC., et al. 2005. J Neurosci Res. 82: 762-70. PMID: 16273547
- NFATc4 and ATF3 negatively regulate adiponectin gene expression in 3T3-L1 adipocytes. | Kim, HB., et al. 2006. Diabetes. 55: 1342-52. PMID: 16644691
- Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4. | Yang, TT., et al. 2008. Mol Cell Biol. 28: 3489-501. PMID: 18347059
- Regulation of the stability and transcriptional activity of NFATc4 by ubiquitination. | Fan, Y., et al. 2008. FEBS Lett. 582: 4008-14. PMID: 19026640
- Up-regulation of NFATc4 involves in neuronal apoptosis following intracerebral hemorrhage. | Li, L., et al. 2013. Cell Mol Neurobiol. 33: 893-905. PMID: 23852416
- Spatiotemporal changes in NFATc4 expression of retinal ganglion cells after light-induced damage. | Xu, Y., et al. 2014. J Mol Neurosci. 53: 69-77. PMID: 24362677
- Involvement of calcineurin/NFATc4 pathway in a single-prolonged stress-based rat model of post-traumatic stress disorder. | Su, Q., et al. 2019. Mol Biol Rep. 46: 6197-6204. PMID: 31486013
- Inhibition of calcineurin/NFATc4 signaling attenuates ventilator‑induced lung injury. | Li, M., et al. 2020. Mol Med Rep. 21: 607-614. PMID: 31789412
- Increased NFATC4 Correlates With Poor Prognosis of AML Through Recruiting Regulatory T Cells. | Zhao, C., et al. 2020. Front Genet. 11: 573124. PMID: 33329712
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NFATc4 Antibody (A-2) | sc-271127 | 200 µg/ml | $322.00 | |||
NFATc4 Antibody (A-2): m-IgG2b BP-HRP Bundle | sc-548536 | 200 µg Ab; 10 µg BP | $361.00 | |||
NFATc4 Antibody (A-2) X | sc-271127 X | 200 µg/0.1 ml | $322.00 |