NCAM/CD56 Antibody (D-10): sc-374289

NCAM Antibody (D-10) is a mouse monoclonal IgG2a kappa light chain antibody specifically designed to target the Neural Cell Adhesion Molecule (NCAM), also known as CD56. anti-NCAM antibody (D-10) is raised against amino acids 1-300 at the N-terminus of human NCAM, ensuring precise recognition and binding. NCAM (D-10) antibody is highly effective for detecting human NCAM in various applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). NCAM is a vital cell surface glycoprotein involved in mediating cell-to-cell interactions, playing a crucial role in embryogenesis, neural development, and synaptic plasticity. NCAM facilitates important biological processes such as neurite outgrowth and neuronal differentiation by interacting with proteins like fibroblast growth factor receptors (FGFRs), integrins, and intracellular signaling molecules such as Fyn and focal adhesion kinase (FAK). Beyond its essential functions in normal physiology, NCAM is a significant marker in various human tumors, including neuroblastomas, rhabdomyosarcomas, Wilms′ tumor, and Ewing′s sarcoma. NCAM (D-10) monoclonal antibody is an invaluable tool for researchers studying the molecular mechanisms underlying neural development and tumor biology, providing reliable detection and analysis of NCAM expression. anti-NCAM antibody (D-10) supports advancements in both developmental biology and cancer research by facilitating the investigation of NCAM interactions and signaling pathways.

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NCAM/CD56 Antibody (D-10) References:

1. Polyclonal antibodies against NCAM reduce paralysis-induced axonal sprouting.  |  Schäfer, R. and Wernig, A. 1998. J Neurocytol. 27: 615-24. PMID: 10405028
2. The neural cell adhesion molecule in synaptic plasticity and ageing.  |  Rønn, LC., et al. 2000. Int J Dev Neurosci. 18: 193-9. PMID: 10715574
3. Neural cell adhesion molecule (NCAM) and myoblast fusion.  |  Charlton, CA., et al. 2000. Dev Biol. 221: 112-9. PMID: 10772795
4. Regulation of hippocampal cell adhesion molecules NCAM and L1 by contextual fear conditioning is dependent upon time and stressor intensity.  |  Merino, JJ., et al. 2000. Eur J Neurosci. 12: 3283-90. PMID: 10998112
5. Sialylated form of the neural cell adhesion molecule (NCAM): a new tool for the identification and sorting of beta-cell subpopulations with different functional activity.  |  Bernard-Kargar, C., et al. 2001. Diabetes. 50 Suppl 1: S125-30. PMID: 11272170
6. Localization and characterization of polysialic acid-containing N-linked glycans from bovine NCAM.  |  von Der Ohe, M., et al. 2002. Glycobiology. 12: 47-63. PMID: 11825886
7. The synthetic NCAM-derived peptide, FGL, modulates the transcriptional response to traumatic brain injury.  |  Pedersen, MV., et al. 2008. Neurosci Lett. 437: 148-53. PMID: 18436381
8. Binding of the receptor tyrosine kinase TrkB to the neural cell adhesion molecule (NCAM) regulates phosphorylation of NCAM and NCAM-dependent neurite outgrowth.  |  Cassens, C., et al. 2010. J Biol Chem. 285: 28959-67. PMID: 20605779
9. UCHL1 regulates ubiquitination and recycling of the neural cell adhesion molecule NCAM.  |  Wobst, H., et al. 2012. FEBS J. 279: 4398-409. PMID: 23061666
10. Brain structure, cognition and negative symptoms in schizophrenia are associated with serum levels of polysialic acid-modified NCAM.  |  Piras, F., et al. 2015. Transl Psychiatry. 5: e658. PMID: 26460482

The preferred NCAM/CD56 antibody is NCAM/CD56 Antibody (ERIC 1): sc-106.