melanopsin Antibody (E-12): sc-515838

melanopsin Antibody (E-12) is a mouse monoclonal IgM antibody that detects melanopsin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-melanopsin antibody (E-12) is available as the non-conjugated form. Melanopsin, a member of the opsin family, is a G protein-coupled receptor that plays a crucial role in the regulation of circadian rhythms and the pupillary light reflex. Melanopsin is primarily located in the inner retina, specifically in intrinsically photosensitive retinal ganglion cells, which are distinct from the traditional photoreceptor cells responsible for image formation. The unique localization of melanopsin allows these cells to respond to ambient light levels, thereby influencing various non-image-forming visual functions. Activation of melanopsin by light leads to a cascade of intracellular signaling events that ultimately affect physiological processes such as sleep-wake cycles and hormone release. Given its essential role in light detection and circadian regulation, melanopsin is a vital target for research into sleep disorders and other light-related health issues.

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melanopsin Antibody (E-12) References:

1. A novel human opsin in the inner retina.  |  Provencio, I., et al. 2000. J Neurosci. 20: 600-5. PMID: 10632589
2. Crystal structure of rhodopsin: A G protein-coupled receptor.  |  Palczewski, K., et al. 2000. Science. 289: 739-45. PMID: 10926528
3. Role of melanopsin in circadian responses to light.  |  Ruby, NF., et al. 2002. Science. 298: 2211-3. PMID: 12481140
4. Targeting Opsin4/Melanopsin with a Novel Small Molecule Suppresses PKC/RAF/MEK/ERK Signaling and Inhibits Lung Adenocarcinoma Progression.  |  Wang, Q., et al. 2020. Mol Cancer Res. 18: 1028-1038. PMID: 32269074
5. Melanopsin mediates UVA-dependent modulation of proliferation, pigmentation, apoptosis, and molecular clock in normal and malignant melanocytes.  |  de Assis, LVM., et al. 2020. Biochim Biophys Acta Mol Cell Res. 1867: 118789. PMID: 32645331
6. Melanopsin modulates refractive development and myopia.  |  Chakraborty, R., et al. 2022. Exp Eye Res. 214: 108866. PMID: 34838844
7. Melanopsin (Opn4) is an oncogene in cutaneous melanoma.  |  de Assis, LVM., et al. 2022. Commun Biol. 5: 461. PMID: 35562405
8. Melanopsin retinal ganglion cells mediate light-promoted brain development.  |  Hu, J., et al. 2022. Cell. 185: 3124-3137.e15. PMID: 35944541
9. Optogenetic activation of mGluR1 signaling in the cerebellum induces synaptic plasticity.  |  Surdin, T., et al. 2023. iScience. 26: 105828. PMID: 36632066
10. The structure of bovine rhodopsin.  |  Hargrave, PA., et al. 1983. Biophys Struct Mech. 9: 235-44. PMID: 6342691
11. G-protein diseases furnish a model for the turn-on switch.  |  Iiri, T., et al. 1998. Nature. 394: 35-8. PMID: 9665125
12. Flow of information in the light-triggered cyclic nucleotide cascade of vision.  |  Fung, BK., et al. 1981. Proc Natl Acad Sci U S A. 78: 152-6. PMID: 6264430

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-melanopsin Antibody (E-12) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-melanopsin Antibody (E-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

melanopsin Antibody (E-12) Specifications

Alternate Product Name: melanopsin

Product Clone Name: E-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 430-451

Epitope Target: melanopsin

Epitope Species: rat

Product Reactivity/Detection: melanopsin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for melanopsin Antibody (E-12): N/A