Lamin A/C Antibody (4C11): sc-517579

Lamin A/C Antibody (4C11) is a mouse monoclonal IgG2a antibody that detects Lamin A/C in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Lamin A/C plays a crucial role in maintaining the structural integrity of the nuclear envelope, which is essential for proper cellular function and organization. Anti-Lamin A/C antibody (4C11) targets proteins located in the nuclear lamina, a dense fibrillar network inside the nucleus, where Lamin A/C provides mechanical support and regulates important processes such as DNA replication and cell division. Lamin A/C monoclonal antibody (4C11) enables research beyond structural support, as Lamin A/C is involved in chromatin organization and gene expression regulation. Notably, mutations in the Lamin A gene can lead to a variety of diseases, including muscular dystrophies and progeria, highlighting the importance of Lamin A/C in cellular health and longevity. Lamin A/C (4C11) antibody serves as an invaluable tool for researchers studying the dynamics of the nuclear envelope and its implications in various pathologies, enabling deeper insights into the molecular mechanisms underlying cellular aging and disease progression.

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Lamin A/C Antibody (4C11) References:

1. Lamin A/C Cardiomyopathies: Current Understanding and Novel Treatment Strategies.  |  Wang, X., et al. 2017. Curr Treat Options Cardiovasc Med. 19: 21. PMID: 28299614
2. Expression of Lamin A/C in early-stage breast cancer and its prognostic value.  |  Alhudiri, IM., et al. 2019. Breast Cancer Res Treat. 174: 661-668. PMID: 30610489
3. Lamin A/C modulates spatial organization and function of the Hsp70 gene locus via nuclear myosin I.  |  Pradhan, R., et al. 2020. J Cell Sci. 133: PMID: 31988151
4. Dimensionality changes actin network through lamin A/C and zyxin.  |  Zonderland, J., et al. 2020. Biomaterials. 240: 119854. PMID: 32087459
5. Lamin A/C Assembly Defects in LMNA-Congenital Muscular Dystrophy Is Responsible for the Increased Severity of the Disease Compared with Emery-Dreifuss Muscular Dystrophy.  |  Bertrand, AT., et al. 2020. Cells. 9: PMID: 32244403
6. Lamin A/C-Dependent Translocation of Megakaryoblastic Leukemia-1 and β-Catenin in Cyclic Strain-Induced Osteogenesis.  |  Khan, AU., et al. 2021. Cells. 10: PMID: 34944031
7. Matrix remodeling controls a nuclear lamin A/C-emerin network that directs Wnt-regulated stem cell fate.  |  Tang, Y., et al. 2022. Dev Cell. 57: 480-495.e6. PMID: 35150612
8. The BAF A12T mutation disrupts lamin A/C interaction, impairing robust repair of nuclear envelope ruptures in Nestor-Guillermo progeria syndrome cells.  |  Janssen, A., et al. 2022. Nucleic Acids Res. 50: 9260-9278. PMID: 36039758
9. The lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding.  |  Wallace, M., et al. 2023. Nucleus. 14: 2180206. PMID: 36809122
10. Lamin A/C and PI(4,5)P2-A Novel Complex in the Cell Nucleus.  |  Escudeiro-Lopes, S., et al. 2024. Cells. 13: PMID: 38474363

The preferred Lamin A/C antibody is Lamin A/C Antibody (636): sc-7292.