IRF-7 Antibody (F-1): sc-74471

IRF-7 Antibody (F-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects IRF-7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-IRF-7 antibody (F-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Interferon regulatory factor 7 (IRF-7) plays a crucial role in immune response by regulating type I interferons, which are vital for antiviral defense. Located primarily in the nucleus, IRF-7 becomes activated in response to viral infections and is essential for transcriptional activation of interferon-α and interferon-β genes. This nuclear localization enables IRF-7 to quickly respond to viral signals and initiate immune response, enhancing host′s ability to combat infections. IRF-7 interacts with other proteins in interferon signaling pathway, including IRF-3, which further underscores IRF-7′s importance in regulating immune responses. Formation of protein complexes by IRF-7 highlights a critical role in fine-tuning immune response, making IRF-7 an important target for research in immunology and virology.

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IRF-7 Antibody (F-1) References:

1. IRF-7 is the master regulator of type-I interferon-dependent immune responses.  |  Honda, K., et al. 2005. Nature. 434: 772-7. PMID: 15800576
2. Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages.  |  Solis, M., et al. 2006. Biochem Pharmacol. 72: 1469-76. PMID: 16846591
3. Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.  |  Paz, S., et al. 2006. Cell Mol Biol (Noisy-le-grand). 52: 17-28. PMID: 16914100
4. IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling.  |  Lazear, HM., et al. 2013. PLoS Pathog. 9: e1003118. PMID: 23300459
5. Synergistic control of herpes simplex virus pathogenesis by IRF-3, and IRF-7 revealed through non-invasive bioluminescence imaging.  |  Murphy, AA., et al. 2013. Virology. 444: 71-9. PMID: 23777662
6. The roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus.  |  Chen, HW., et al. 2013. J Immunol. 191: 4194-201. PMID: 24043884
7. IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation.  |  He, J., et al. 2019. Cell Rep. 29: 2718-2730.e6. PMID: 31775040
8. IRF-7 Mediates Type I IFN Responses in Endotoxin-Challenged Mice.  |  Sin, WX., et al. 2020. Front Immunol. 11: 640. PMID: 32373120
9. TLR4-Associated IRF-7 and NFκB Signaling Act as a Molecular Link Between Androgen and Metformin Activities and Cytokine Synthesis in the PCOS Endometrium.  |  Hu, M., et al. 2021. J Clin Endocrinol Metab. 106: 1022-1040. PMID: 33382900
10. Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis.  |  Peng, Y., et al. 2024. Cell Mol Biol Lett. 29: 61. PMID: 38671352

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IRF-7 Antibody (F-1) has 22 citations in a variety of scientific publications.

Primary antibodies like Anti-IRF-7 Antibody (F-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IRF-7 Antibody (F-1) Specifications

Alternate Product Name: IRF-7

Product Clone Name: F-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-246

Epitope Target: IRF-7

Epitope Species: human

Product Reactivity/Detection: IRF-7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 22 citations in various scientific publications

Available Conjugates/Forms for IRF-7 Antibody (F-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred IRF-7 antibody is IRF-7 Antibody (G-8): sc-74472.