IL-8 Antibody (NYR-HIL8): sc-73321

IL-8 Antibody (NYR-HIL8) is a mouse monoclonal IgG1 antibody that detects interleukin-8 (IL-8) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). IL-8 is a crucial chemokine that plays a significant role in the immune response by acting as a chemoattractant for neutrophils, thereby facilitating their migration to sites of inflammation. This function is particularly important in the context of chronic inflammatory diseases, such as inflammatory bowel disease and atherosclerosis, where elevated levels of IL-8 have been observed. The protein is initially synthesized as a 99 amino acid precursor, which is then cleaved to produce a biologically active 72 amino acid form. Notably, IL-8 exists in both monomeric and dimeric forms, with dimerization serving as a negative regulator of IL-8 receptor function. The receptors for IL-8, IL-8RA and IL-8RB, are seven-transmembrane domain proteins that share a high degree of sequence identity and are also involved in the signaling of other chemokines. Anti-IL-8 antibody (NYR-HIL8) is an essential tool for researchers studying the complex roles of IL-8 in immune responses and its implications in various diseases.

The preferred IL-8 antibody is IL-8 Antibody (C-11): sc-376750.