IL-27Rα Antibody (F-7): sc-376309

IL-27Rα Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects IL-27R alpha protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-27Rα (F-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-27R alpha protein plays a crucial role in immune response by serving as a receptor for cytokine IL-27, which is essential for differentiation and expansion of naive CD4-positive T cells into effector T cells. This process is vital for developing a robust adaptive immune response, particularly during infections and inflammation. IL-27R alpha interaction with IL-27 (also known as WSX-1) activates downstream signaling pathways, including phosphorylation of Stat1 and Stat3, which are critical for transcriptional regulation of genes involved in T cell differentiation. IL-27R alpha is predominantly expressed on naive T cells, highlighting importance in initiating immune responses rather than modulating memory T cell functions. IL-27′s ability to enhance interferon-gamma production from T cells further underscores significance in shaping immune landscape, making anti-IL-27Rα antibody (F-7) an invaluable tool for researchers studying T cell biology and immune regulation.

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IL-27Rα Antibody (F-7) References:

1. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.  |  Pflanz, S., et al. 2002. Immunity. 16: 779-90. PMID: 12121660
2. IL-23 and IL-27: new members of the growing family of IL-12-related cytokines with important implications for therapeutics.  |  Cordoba-Rodriguez, R. and Frucht, DM. 2003. Expert Opin Biol Ther. 3: 715-23. PMID: 12880372
3. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms.  |  Lucas, S., et al. 2003. Proc Natl Acad Sci U S A. 100: 15047-52. PMID: 14657353
4. Understanding the pro- and anti-inflammatory properties of IL-27.  |  Villarino, AV., et al. 2004. J Immunol. 173: 715-20. PMID: 15240655
5. Suppression of ongoing adjuvant-induced arthritis by neutralizing the function of the p28 subunit of IL-27.  |  Goldberg, R., et al. 2004. J Immunol. 173: 1171-8. PMID: 15240707
6. Induction of IgG2a class switching in B cells by IL-27.  |  Yoshimoto, T., et al. 2004. J Immunol. 173: 2479-85. PMID: 15294962
7. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity.  |  Artis, D., et al. 2004. J Immunol. 173: 5626-34. PMID: 15494513
8. The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis.  |  Hölscher, C., et al. 2005. J Immunol. 174: 3534-44. PMID: 15749890

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-27Rα Antibody (F-7) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-27Rα Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-27Rα Antibody (F-7) Specifications

Alternate Product Name: IL-27Rα

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 91-340

Epitope Target: IL-27Rα

Epitope Species: human

Product Reactivity/Detection: IL-27Rα

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for IL-27Rα Antibody (F-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin