IL-1 beta/IL1B Antibody (B122): sc-12742
- IL-1 beta/IL1B Antibody (B122) is a Armenian hamster monoclonal IgG IL-1 beta/IL1B antibody, cited in 169 publications, provided at 200 µg/ml
- raised against the mature form of IL-1β of mouse origin
- IL-1 beta/IL1B Antibody (B122) is recommended for detection of IL-1β precursor and mature forms of mouse, rat, human and hamster origin by WB, IP and ELISA
- Anti-IL-1 beta/IL1B Antibody (B122) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also provided azide-free for neutralization, sc-12742 L, 200 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-1 beta/IL1B Antibody (B122). This work is in progress.
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IL-1β Antibody (B122) is a hamster monoclonal IgG antibody that detects IL-1β (B122) of mouse, rat, human, and hamster origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IL-1β (B122) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-1β plays a pivotal role in the immune response and inflammation, acting as a key mediator that influences the activity of T and B lymphocytes as well as natural killer (NK) cells. Notably, IL-1β is produced in response to inflammatory stimuli and is crucial for the activation of immune cells, promoting the secretion of other cytokines such as IL-2 while inhibiting IL-4 expression in T cells. This regulatory function is essential for maintaining a balanced immune response, and dysregulation of IL-1β has been linked to various pathological conditions, including rheumatoid arthritis and inflammatory bowel disease. The ability of IL-1β to induce B cell proliferation and immunoglobulin synthesis further underscores its importance in adaptive immunity. By utilizing IL-1β (B122) antibody in research, you can gain valuable insights into the mechanisms of inflammation and immune regulation, contributing to a better understanding of both normal physiological processes and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-1 beta/IL1B Antibody (B122) References:
- Structural differences between the putative carbohydrate-recognition domains of human IL-1 alpha, IL-1 beta and IL-1 receptor antagonist obtained by in silico modeling. | Vergoten, G. and Zanetta, JP. 2007. Glycoconj J. 24: 183-93. PMID: 17340198
- A new microrheometric approach reveals individual and cooperative roles for TGF-beta1 and IL-1beta in fibroblast-mediated stiffening of collagen gels. | Leung, LY., et al. 2007. FASEB J. 21: 2064-73. PMID: 17341683
- Interleukin-1 and interleukin-1 antagonism. | Dinarello, CA. 1991. Blood. 77: 1627-52. PMID: 1826616
- Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. | March, CJ., et al. Nature. 315: 641-7. PMID: 2989698
- Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. | Auron, PE., et al. 1984. Proc Natl Acad Sci U S A. 81: 7907-11. PMID: 6083565
- Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation. | Zúñiga-Pflücker, JC., et al. 1995. Science. 268: 1906-9. PMID: 7541554
- Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor. | Sadouk, MB., et al. 1995. Lab Invest. 73: 347-55. PMID: 7564267
- IL-4 expression in human T cells is selectively inhibited by IL-1 alpha and IL-1 beta. | Sandborg, CI., et al. 1995. J Immunol. 155: 5206-12. PMID: 7594531
- Cytokines in human renal interstitial fibrosis. I. Interleukin-1 is a paracrine growth factor for cultured fibrosis-derived kidney fibroblasts. | Lonnemann, G., et al. 1995. Kidney Int. 47: 837-44. PMID: 7752582
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-1 beta/IL1B Antibody (B122) | sc-12742 | 200 µg/ml | $322.00 | |||
IL-1 beta/IL1B Antibody (B122) L | sc-12742 L | 200 µg/0.1 ml | $322.00 | |||
IL-1 beta/IL1B Antibody (B122) AC | sc-12742 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IL-1 beta/IL1B Antibody (B122) HRP | sc-12742 HRP | 200 µg/ml | $322.00 | |||
IL-1 beta/IL1B Antibody (B122) FITC | sc-12742 FITC | 200 µg/ml | $336.00 | |||
IL-1 beta/IL1B Antibody (B122) PE | sc-12742 PE | 200 µg/ml | $349.00 | |||
IL-1 beta/IL1B Antibody (B122) Alexa Fluor® 488 | sc-12742 AF488 | 200 µg/ml | $364.00 | |||
IL-1 beta/IL1B Antibody (B122) Alexa Fluor® 546 | sc-12742 AF546 | 200 µg/ml | $364.00 | |||
IL-1 beta/IL1B Antibody (B122) Alexa Fluor® 594 | sc-12742 AF594 | 200 µg/ml | $364.00 | |||
IL-1 beta/IL1B Antibody (B122) Alexa Fluor® 647 | sc-12742 AF647 | 200 µg/ml | $364.00 | |||
IL-1 beta/IL1B Antibody (B122) Alexa Fluor® 680 | sc-12742 AF680 | 200 µg/ml | $364.00 | |||
IL-1 beta/IL1B Antibody (B122) Alexa Fluor® 790 | sc-12742 AF790 | 200 µg/ml | $364.00 |