IL-16 Antibody (B-2): sc-374604

IL-16 Antibody (B-2) is a mouse monoclonal IgG2a antibody that detects interleukin-16 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-16 is a crucial cytokine known for its role as a lymphocyte chemoattractant factor, particularly for CD4+ T lymphocytes, which are essential for orchestrating immune responses. Anti-IL-16 antibody (B-2) recognizes protein secreted by activated eosinophils during allergic reactions, highlighting its importance in mediating inflammation and immune regulation. Upon binding to CD4 receptor, IL-16 triggers a cascade of intracellular signaling events, including the activation of protein kinase C (PKC) pathways, which are vital for the proliferation and differentiation of T cells. The ability of IL-16 to attract CD4+ T lymphocytes to sites of inflammation underscores its significance in both normal immune function and pathological conditions, such as allergies and autoimmune diseases. IL-16 monoclonal antibody (B-2) serves as an invaluable tool for researchers studying the complex interactions within the immune system and the mechanisms underlying inflammatory responses.

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IL-16 Antibody (B-2) References:

1. IL-16 inhibits IL-5 production by antigen-stimulated T cells in atopic subjects.  |  Pinsonneault, S., et al. 2001. J Allergy Clin Immunol. 107: 477-82. PMID: 11240948
2. Emerging role of IL-16 in cytokine-mediated regulation of multiple sclerosis.  |  Skundric, DS., et al. 2015. Cytokine. 75: 234-48. PMID: 25703787
3. IL-14 and IL-16 are expressed in the thyroid of patients with either Graves' disease or Hashimoto's thyroiditis.  |  Kemp, EH., et al. 2015. Clin Endocrinol (Oxf). 83: 726-32. PMID: 25940130
4. IL-17A Promotes RANTES Expression, But Not IL-16, in Orbital Fibroblasts Via CD40-CD40L Combination in Thyroid-Associated Ophthalmopathy.  |  Fang, S., et al. 2016. Invest Ophthalmol Vis Sci. 57: 6123-6133. PMID: 27832278
5. The role of IL‑16 gene polymorphisms in endometriosis.  |  Matalliotakis, M., et al. 2018. Int J Mol Med. 41: 1469-1476. PMID: 29328375
6. Elevated IL-16 expression is associated with development of immune dysfunction in children with autism.  |  Ahmad, SF., et al. 2019. Psychopharmacology (Berl). 236: 831-838. PMID: 30456538
7. IL-16 regulates macrophage polarization as a target gene of mir-145-3p.  |  Huang, Y., et al. 2019. Mol Immunol. 107: 1-9. PMID: 30634164
8. IL-16 expression is increased in the skin and sera of patients with systemic sclerosis.  |  Kawabata, K., et al. 2020. Rheumatology (Oxford). 59: 519-523. PMID: 31377804
9. IL-16 and BCA-1 Serum Levels Are Associated with Disease Severity of C. difficile Infection.  |  Gotshal, D., et al. 2021. Pathogens. 10: PMID: 34065379
10. IL-16 exerts anti-rabies virus effects through CD9 on the surface of viral particles.  |  Zhang, T., et al. 2025. Int J Biol Macromol. 305: 141042. PMID: 39956243

The preferred IL-16 antibody is IL-16 Antibody (A-1): sc-374606.