IKKβ Antibody (24): sc-135948
- IKKβ Antibody (24) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/500 µl
- raised against amino acids 629-735 of IKKβ of human origin
- recommended for detection of IKKβ of human and canine origin by WB, IP and IF
- See IKKβ (H-4): sc-8014 for IKKβ antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IKKβ Antibody (24). This work is in progress.
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IKKβ Antibody (24) is a mouse monoclonal IgG1 antibody that detects IKKβ in human and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). IKKβ, a key component of the IKK complex, plays a crucial role in the activation of the transcription factor NFkB, which is essential for regulating immune responses, cell survival, and inflammation. IKKβ is primarily located in the cytoplasm, where IKKβ interacts with regulatory partners to facilitate the phosphorylation of IkB proteins, leading to their degradation and the subsequent release of NFkB. This process is vital for the cellular response to proinflammatory cytokines, as NFkB can translocate to the nucleus and initiate the transcription of target genes involved in inflammation and immune responses. Proper functioning of IKKβ is critical, as dysregulation can lead to various diseases, including cancer and autoimmune disorders. Anti-IKKβ antibody (24) provides a reliable tool for researchers studying the intricate signaling pathways involving NFkB and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IKKβ Antibody (24) References:
- Tyrosine phosphorylation allows integration of multiple signaling inputs by IKKβ. | Meyer, AN., et al. 2013. PLoS One. 8: e84497. PMID: 24386391
- Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma. | Agarwal, NK., et al. 2016. Blood. 127: 605-15. PMID: 26603838
- IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis. | Pallangyo, CK., et al. 2015. J Exp Med. 212: 2253-66. PMID: 26621452
- IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. | Reid, MA., et al. 2016. Genes Dev. 30: 1837-51. PMID: 27585591
- NEMO-IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS-STING Pathway. | Fang, R., et al. 2017. J Immunol. 199: 3222-3233. PMID: 28939760
- IKKβ Kinase Promotes Stemness, Migration, and Invasion in KRAS-Driven Lung Adenocarcinoma Cells. | Rodrigues, FS., et al. 2020. Int J Mol Sci. 21: PMID: 32823550
- Clinicopathological analysis and prognostic significance of NF-κB p65 and IKKβ protein and mRNA expression in nasopharyngeal carcinoma. | Zhou, M., et al. 2022. J Int Med Res. 50: 3000605211069195. PMID: 34994235
- Somatic ablation of IKKβ in liver and leukocytes is not tolerated in obese mice but hepatic IKKβ deletion improves fatty liver and insulin sensitivity. | Silva, VRR., et al. 2022. FASEB J. 36: e22512. PMID: 36001064
- Sustained activation of NF-κB through constitutively active IKKβ leads to senescence bypass in murine dermal fibroblasts. | Harada, M., et al. 2024. Cell Cycle. 23: 308-327. PMID: 38461418
- Esophageal epithelial Ikkβ deletion promotes eosinophilic esophagitis in experimental allergy mouse model. | Clevenger, MH., et al. 2024. bioRxiv.. PMID: 39026724
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IKKβ Antibody (24) | sc-135948 | 50 µg/500 µl | $322.00 |