HspBP1 Antibody (E-3): sc-398319

HspBP1 Antibody (E-3) is a mouse monoclonal IgG1 antibody that detects HspBP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HspBP1, a crucial nucleotide exchange factor for Hsp70, plays a significant role in the maturation of the cystic fibrosis transmembrane conductance regulator (CFTR) by interfering with the CHIP-induced degradation of immature forms, thereby ensuring proper protein folding and function. HspBP1 is predominantly expressed in heart and skeletal muscle, where HspBP1 is essential for maintaining cellular homeostasis and responding to stress conditions. The interaction of HspBP1 with Hsp70 is vital, as HspBP1 inhibits Hsp70′s activity and facilitates the release of nucleotides from its ATPase domain, which is critical for the protein′s chaperone function. By regulating the activity of Hsp70, HspBP1 not only aids in the maturation of CFTR but also contributes to the overall protein quality control within the cell, highlighting HspBP1′s importance in cellular health and disease mechanisms. Anti-HspBP1 antibody (E-3) is an invaluable tool for researchers studying the intricate dynamics of protein interactions and the cellular stress response.

The preferred HspBP1 antibody is HspBP1 Antibody (F-11): sc-390467.