HNF-1 alpha Antibody (2): sc-135939

HNF-1α Antibody (2) is a mouse monoclonal IgG1 antibody that detects HNF-1α in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). HNF-1α is a crucial transcription factor that plays a significant role in regulating gene expression in the liver and other tissues, including the kidney and small intestine. HNF-1α is essential for maintaining metabolic homeostasis and is involved in the transcriptional regulation of various genes vital for liver function, such as those involved in glucose and lipid metabolism. Proper functioning of HNF-1α is particularly important because mutations in the HNF-1α gene can lead to maturity-onset diabetes of the young (MODY), a form of diabetes characterized by early onset and a strong genetic component. Additionally, HNF-1α interacts with other members of the hepatocyte nuclear factor family, such as HNF-4α, to coordinate the expression of genes necessary for liver development and function. HNF-1α′s ability to bind to specific DNA sequences in the promoter regions of target genes underscores its importance in the regulation of metabolic pathways, making anti-HNF-1α antibody (2) an invaluable tool for researchers studying these pathways and their implications in health and disease.

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HNF-1 alpha Antibody (2) References:

1. Functional dissection of the HNF-1alpha transcription factor: a study on nuclear localization and transcriptional activation.  |  Bjørkhaug, L., et al. 2005. DNA Cell Biol. 24: 661-9. PMID: 16274290
2. HNF-1alpha participates in glucose regulation of sucrase-isomaltase gene expression in epithelial intestinal cells.  |  Gu, N., et al. 2007. Biochem Biophys Res Commun. 353: 617-22. PMID: 17194452
3. Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas.  |  Nammo, T., et al. 2008. Gene Expr Patterns. 8: 96-106. PMID: 17996499
4. NR2F1 disrupts synergistic activation of the MTTP gene transcription by HNF-4α and HNF-1α.  |  Dai, K. and Hussain, MM. 2012. J Lipid Res. 53: 901-908. PMID: 22357705
5. Hepatic Nuclear Factor 1 Alpha (HNF-1α) In Human Physiology and Molecular Medicine.  |  Begum, S. 2020. Curr Mol Pharmacol. 13: 50-56. PMID: 31566143
6. Disruption of Tumor Suppressors HNF4α/HNF1α Causes Tumorigenesis in Liver.  |  Teeli, AS., et al. 2021. Cancers (Basel). 13: PMID: 34771521
7. Dominant-negative HNF1α mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D.  |  Liu, M., et al. 2023. iScience. 26: 108018. PMID: 37841581
8. HNF1α maintains pancreatic α and β cell functions in primary human islets.  |  Qian, MF., et al. 2023. JCI Insight. 8: PMID: 37943614
9. SPOP inhibits HBV transcription and replication by ubiquitination and degradation of HNF1α.  |  Pi, Y., et al. 2023. J Med Virol. 95: e29254. PMID: 38018242
10. Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α.  |  Peng, Y., et al. 2024. Cell Death Dis. 15: 416. PMID: 38879600

The preferred HNF-1α antibody is HNF-1α Antibody (F-7): sc-393925.