raised against partially purified vesicles containing Glut4 derived from rat adipocytes
Glucose Transporter Glut4 Antibody (IF8) é raccomandato per il rilevamento di Glut4 di origine mouse, rat e human in WB, IP, IF e IHC(P)
Glucose Transporter Glut4 Antibody (IF8) é disponibile coniugato con agarose per IP; HRP per WB, IHC(P) ed ELISA; sia con phycoerythrin o FITC per IF, IHC(P) e FCM
disponibile anche coniugato con Alexa Fluor® 488, Alexa Fluor® 546; Alexa Fluor® 594 o Alexa Fluor® 647 per IF, IHC (P) e FCM
disponibile anche coniugato con Alexa Fluor® 680 o Alexa Fluor® 790 per WB (NIR), IF e FCM
Contattaci per ricevere un FREE 10 µg sample di Glucose Transporter Glut4 (IF8): sc-53566.
m-IgG Fc BP-HRP (mouse IgG Fc binding protein-HRP) and m-IgG1 BP-HRP (mouse IgG1 binding protein-HRP) are the preferred secondary detection reagents for Glucose Transporter Glut4 Antibody (IF8) for WB and IHC(P) applications. These reagents are now offered in bundles with Glucose Transporter Glut4 Antibody (IF8) (see ordering information below).
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Glut4 Antibody (IF8) is a high quality monoclonal Glut4 antibody (also designated Glucose transporter type 4 antibody, GLUT-4 antibody, or SLC2A4 antibody) suitable for the detection of the Glut4 protein of mouse, rat and human origin. Glut4 Antibody (IF8) is available as both the non-conjugated anti-Glut4 antibody form, as well as multiple conjugated forms of anti-Glut4 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Glucose is fundamental to the metabolism of mammalian cells. Its passage across cell membranes is mediated by a family of transporters termed glucose transporters or Gluts. In adipose and muscle tissue, insulin stimulates a rapid and dramatic increase in glucose uptake, which is largely due to the redistribution of the insulin-inducible glucose transporter, Glut4. In response to insulin, Glut4 is quickly shuttled from an intracellular storage site to the plasma membrane, where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane, and shows a much less dramatic translocation in response to insulin. Glut1 and Glut4 are twelve-pass transmembrane proteins (12TM) whose carboxy-termini may dictate their cellular localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 null mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellular glucose, fat metabolism and prolonged longevity.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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