elastin Antibody (A-8): sc-374638
- elastin Antibody (A-8) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 371-407 within an internal region of elastin of human origin
- Anti-elastin Antibody (A-8) is recommended for detection of precursor tropoelastin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-elastin Antibody (A-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for elastin Antibody (A-8) for WB applications. This reagent is now offered in a bundle with elastin Antibody (A-8) (see ordering information below).
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Elastin Antibody (A-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects elastin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-elastin antibody (A-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Elastin plays a crucial role in the extracellular matrix, primarily found in connective tissues, where elastin provides elasticity and resilience, allowing tissues to stretch and return to their original shape. This property is particularly important in structures that undergo frequent deformation, such as blood vessels, lungs, and skin. The unique structure of elastin, characterized by a high content of glycine, proline, and hydrophobic residues, enables elastin to form a rubber-like network through lysine-derived crosslinks, including desmosines. These crosslinks are vital for maintaining tissue elasticity; however, as individuals age, the cross-linking of collagen with elastin can lead to decreased tissue elasticity, contributing to age-related disorders. Furthermore, deficiencies in elastin are linked to various health conditions, including supravalvular aortic stenosis and Williams-Beuren syndrome, highlighting elastin′s significance in vascular health and development. The human elastin gene is located on chromosome 7q11.23, underscoring elastin′s genetic importance in the context of these disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
elastin Antibody (A-8) References:
- Elastin as a biomaterial for tissue engineering. | Daamen, WF., et al. 2007. Biomaterials. 28: 4378-98. PMID: 17631957
- Elastin peptides antagonize ceramide-induced apoptosis. | Cantarelli, B., et al. 2009. FEBS Lett. 583: 2385-91. PMID: 19559025
- Emerging applications of multifunctional elastin-like recombinamers. | Rodríguez-Cabello, JC., et al. 2011. Nanomedicine (Lond). 6: 111-22. PMID: 21182423
- Biodegradation of elastin-like polypeptide nanoparticles. | Shah, M., et al. 2012. Protein Sci. 21: 743-50. PMID: 22434766
- Structure of the elastin gene and alternative splicing of elastin mRNA: implications for human disease. | Indik, Z., et al. 1989. Am J Med Genet. 34: 81-90. PMID: 2683784
- Genipin Cross-Linking of Elastin and Elastin-Based Proteins. | Muiznieks, LD. 2018. Methods Mol Biol. 1798: 213-221. PMID: 29868963
- Structural Analysis of Nonapeptides Derived from Elastin. | Hernández, B., et al. 2020. Biophys J. 118: 2755-2768. PMID: 32396850
- Vitamin C, lactoferrin and elastin-Advancing the science. | Widgerow, AD. and Ziegler, ME. 2024. J Cosmet Dermatol. 23: 964-969. PMID: 38332665
- A role of copper in elastin formation. | Hill, CH. 1969. Nutr Rev. 27: 99-100. PMID: 4895885
- Conformational transitions of alpha-elastin. | Tamburro, AM., et al. 1977. Biochim Biophys Acta. 492: 370-6. PMID: 884137
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
elastin Antibody (A-8) | sc-374638 | 200 µg/ml | $322.00 | |||
elastin Antibody (A-8): m-IgG1 BP-HRP Bundle | sc-531712 | 200 µg Ab; 20 µg BP | $361.00 | |||
elastin Antibody (A-8) AC | sc-374638 AC | 500 µg/ml, 25% agarose | $424.00 | |||
elastin Antibody (A-8) HRP | sc-374638 HRP | 200 µg/ml | $322.00 | |||
elastin Antibody (A-8) FITC | sc-374638 FITC | 200 µg/ml | $336.00 | |||
elastin Antibody (A-8) PE | sc-374638 PE | 200 µg/ml | $349.00 | |||
elastin Antibody (A-8) Alexa Fluor® 488 | sc-374638 AF488 | 200 µg/ml | $364.00 | |||
elastin Antibody (A-8) Alexa Fluor® 546 | sc-374638 AF546 | 200 µg/ml | $364.00 | |||
elastin Antibody (A-8) Alexa Fluor® 594 | sc-374638 AF594 | 200 µg/ml | $364.00 | |||
elastin Antibody (A-8) Alexa Fluor® 647 | sc-374638 AF647 | 200 µg/ml | $364.00 | |||
elastin Antibody (A-8) Alexa Fluor® 680 | sc-374638 AF680 | 200 µg/ml | $364.00 | |||
elastin Antibody (A-8) Alexa Fluor® 790 | sc-374638 AF790 | 200 µg/ml | $364.00 | |||
elastin (A-8) Neutralizing Peptide | sc-374638 P | 100 µg/0.5 ml | $69.00 |