EBV EBNA-1 Antibody (1EB6): sc-81580

EBV EBNA-1 Antibody (1EB6) is a mouse monoclonal IgG1 antibody that detects EBV EBNA-1 in human samples through immunoprecipitation (IP). EBV EBNA-1 is a crucial protein expressed in all Epstein-Barr virus-associated tumors, including Burkitt′s lymphoma and nasopharyngeal carcinoma, playing a vital role in the synthesis and maintenance of the Epstein-Barr virus genome. EBV EBNA-1 is essential for the virus′s ability to transform human B cells, which is significant given its association with various malignancies. EBV EBNA-1 contains a unique glycine-alanine repeat that is important for its function in the viral life cycle, as this repeat facilitates binding to the viral genome, ensuring replication and persistence within host cells. Additionally, EBV EBNA-1 interacts with other viral proteins, such as EBV EBNA-2, which activates transcription of specific genes necessary for B lymphocyte transformation. The ability of EBV EBNA-1 to modulate host cell processes underscores its importance in the pathogenesis of EBV-related diseases, making anti-EBV EBNA-1 antibody (1EB6) a valuable tool for researchers studying the mechanisms of EBV infection and its associated oncogenic processes.

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EBV EBNA-1 Antibody (1EB6) References:

1. The oncogenic potential of Epstein-Barr virus nuclear antigen 1 in transgenic mice.  |  Wilson, JB. and Levine, AJ. 1992. Curr Top Microbiol Immunol. 182: 375-84. PMID: 1337032
2. Epstein-Barr virus nuclear antigen 1 (EBNA1) protein induction of epithelial-mesenchymal transition in nasopharyngeal carcinoma cells.  |  Wang, L., et al. 2014. Cancer. 120: 363-72. PMID: 24190575
3. Epstein-Barr virus-encoded EBNA1 and ZEBRA: targets for therapeutic strategies against EBV-carrying cancers.  |  Daskalogianni, C., et al. 2015. J Pathol. 235: 334-41. PMID: 25186125
4. Lymphomas driven by Epstein-Barr virus nuclear antigen-1 (EBNA1) are dependant upon Mdm2.  |  AlQarni, S., et al. 2018. Oncogene. 37: 3998-4012. PMID: 29691476
5. EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers.  |  Jiang, L., et al. 2018. Theranostics. 8: 5307-5319. PMID: 30555548
6. Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model.  |  Jog, NR., et al. 2020. J Autoimmun. 106: 102332. PMID: 31515129
7. Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3.  |  Shire, K., et al. 2021. Virology. 562: 103-109. PMID: 34304093
8. A Preliminary Sequence Analysis of the Epstein-Barr Virus Nuclear Antigen 1 (EBNA1) Carboxy-Terminal Region in Cervical and Ovarian Cancers.  |  Hosseini Tabatabaie, F., et al. 2023. Iran J Pathol. 18: 24-32. PMID: 37383155
9. Sequence variation of the Epstein-Barr virus nuclear antigen 1 (EBNA1) gene in chronic lymphocytic leukemia and healthy volunteer subjects.  |  Vafapour, Z., et al. 2023. Arch Virol. 169: 1. PMID: 38063941
10. Impact of Epstein-Barr Virus Nuclear Antigen 1 on Neuroinflammation in PARK2 Knockout Mice.  |  Cossu, D., et al. 2024. Int J Mol Sci. 25: PMID: 39409029

The preferred EBV EBNA-1 antibody is EBV EBNA-1 Antibody (1EB12): sc-81581.