DENND4B Antibody (F-10): sc-514660

DENND4B Antibody (F-10) is a mouse monoclonal IgM antibody that detects DENND4B protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-DENND4B antibody (F-10) is available as the non-conjugated form. DENND4B protein, also known as KIAA0476, is a 1,496 amino acid protein characterized by the presence of a dDENN domain, a DENN domain, a uDENN domain, a MABP domain, and two pentatricopeptide repeats (PPR). DENND4B plays a crucial role in cellular signaling by activating Rab10, a small GTPase essential for vesicle trafficking and membrane dynamics, particularly in the context of the Golgi apparatus. DENND4B is vital for maintaining cellular homeostasis and facilitating the transport of proteins and lipids, which are critical for various cellular processes. DENND4B gene is located on human chromosome 1, the largest chromosome in the human genome, which spans approximately 260 million base pairs and constitutes about 8% of the genome. Notably, chromosome 1 also harbors other significant genes, such as LMNA, linked to Hutchinson-Gilford progeria, and the MUTYH gene, associated with familial adenomatous polyposis, highlighting the importance of this chromosomal region in human health and disease.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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DENND4B Antibody (F-10) References:

1. Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.  |  Blackwood, DH., et al. 2001. Am J Hum Genet. 69: 428-33. PMID: 11443544
2. New insights into the evolution of chromosome 1.  |  Weise, A., et al. 2005. Cytogenet Genome Res. 108: 217-22. PMID: 15545733
3. Hutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.  |  McClintock, D., et al. 2006. Proc Natl Acad Sci U S A. 103: 2154-9. PMID: 16461887
4. Cell biology: ageing nucleus gets out of shape.  |  Lans, H. and Hoeijmakers, JH. 2006. Nature. 440: 32-4. PMID: 16511477
5. Chromosome 1 abnormalities in multiple myeloma.  |  Marzin, Y., et al. 2006. Anticancer Res. 26: 953-9. PMID: 16619492
6. The DNA sequence and biological annotation of human chromosome 1.  |  Gregory, SG., et al. 2006. Nature. 441: 315-21. PMID: 16710414
7. Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1.  |  Watson, ML., et al. 1990. J Exp Med. 172: 263-72. PMID: 1694218
8. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.  |  Yoshimura, S., et al. 2010. J Cell Biol. 191: 367-81. PMID: 20937701

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DENND4B Antibody (F-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DENND4B Antibody (F-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DENND4B Antibody (F-10) Specifications

Alternate Product Name: DENND4B

Product Clone Name: F-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1121-1145

Epitope Target: DENND4B

Epitope Species: human

Product Reactivity/Detection: DENND4B

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DENND4B Antibody (F-10): P: Blocking Peptide