connexin 46 Antibody (E-10): sc-365393

Connexin 46 Antibody (E-10) is a mouse monoclonal IgG2a antibody that detects connexin 46 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Connexin 46 plays a crucial role in the formation of gap junctions, which are essential for intercellular communication, particularly in the lens of the eye where connexin 46 facilitates the transfer of small molecules and ions between adjacent lens fibers. This communication is vital for maintaining lens transparency and homeostasis; any disruption in connexin 46 expression can lead to severe consequences, such as the development of cataracts. Connexin 46′s structure, characterized by four transmembrane α-helical domains and specific extracellular loops, is integral to function, as variations in these regions can significantly alter channel permeability and gating properties. Given that connexin 46 is one of many isoforms in the connexin family, unique properties underscore the importance of precise regulation of connexin expression in preventing pathological conditions associated with impaired cell communication. Anti-connexin 46 antibody (E-10) is an invaluable tool for researchers investigating the role of gap junctions in cellular processes and disease mechanisms.

The preferred connexin 46 antibody is connexin 46 Antibody (C-3): sc-365394.