CD33 Antibody (E-6): sc-376184
- CD33 Antibody (E-6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 231-340 mapping near the C-terminus of CD33 of human origin
- recommended for detection of precursor and mature forms of CD33 of human origin by WB, IP, IF and ELISA; may cross-react with Siglec-5
- See CD33 (6C5/2): sc-53199 for CD33 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD33 Antibody (E-6) for WB applications. These reagents are now offered in bundles with CD33 Antibody (E-6) (see ordering information below).
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CD33 Antibody (E-6) is a mouse monoclonal IgG1 antibody that detects CD33 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CD33 is a type I transmembrane glycoprotein predominantly expressed on granulocyte and macrophage precursors in the bone marrow, as well as on monocytes in peripheral blood, making CD33 (E-6) antibody a crucial marker for distinguishing myelogenous leukemia cells from other types of leukemia, such as lymphoid or erythroid. CD33′s role as a sialic acid-dependent cell adhesion molecule is particularly important, as CD33 facilitates cell-cell interactions and influences immune responses. Additionally, CD33 is involved in the regulation of myeloid cell activation and differentiation, which underscores CD33′s significance in both normal hematopoiesis and pathological conditions like leukemia. Anti-CD33 antibody (E-6) provides a reliable tool for researchers studying these processes, enabling deeper insights into the mechanisms of immune regulation and potential therapeutic targets in hematological malignancies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD33 Antibody (E-6) References:
- CD33-related siglecs as potential modulators of inflammatory responses. | Crocker, PR., et al. 2012. Ann N Y Acad Sci. 1253: 102-11. PMID: 22352893
- The past and future of CD33 as therapeutic target in acute myeloid leukemia. | Laszlo, GS., et al. 2014. Blood Rev. 28: 143-53. PMID: 24809231
- Novel CD33 antibodies unravel localization, biology and therapeutic implications of CD33 isoforms. | Gbadamosi, MO., et al. 2021. Future Oncol. 17: 263-277. PMID: 33356566
- CD33 rs3865444 as a risk factor for Parkinson's disease. | Siokas, V., et al. 2021. Neurosci Lett. 748: 135709. PMID: 33582190
- CD33 Delineates Two Functionally Distinct NK Cell Populations Divergent in Cytokine Production and Antibody-Mediated Cellular Cytotoxicity. | Hejazi, M., et al. 2021. Front Immunol. 12: 798087. PMID: 35058934
- Human brain sialoglycan ligand for CD33, a microglial inhibitory Siglec implicated in Alzheimer's disease. | Gonzalez-Gil, A., et al. 2022. J Biol Chem. 298: 101960. PMID: 35452678
- Relevance of TMPRSS2, CD163/CD206, and CD33 in clinical severity stratification of COVID-19. | Martínez-Diz, S., et al. 2022. Front Immunol. 13: 1094644. PMID: 36969980
- Treating CD33-Positive de novo Acute Myeloid Leukemia in Pediatric Patients: Focus on the Clinical Value of Gemtuzumab Ozogamicin. | Wijnen, NE., et al. 2023. Onco Targets Ther. 16: 297-308. PMID: 37153641
- CD33 Ameliorates Surgery-Induced Spatial Learning and Memory Impairments Through TREM2. | Zou, J., et al. 2025. Mol Neurobiol. 62: 2180-2190. PMID: 39088031
- Loop33 × 123 CAR-T targeting CD33 and CD123 against immune escape in acute myeloid leukemia. | Ma, H., et al. 2024. Cancer Immunol Immunother. 74: 20. PMID: 39535595
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD33 Antibody (E-6) | sc-376184 | 200 µg/ml | $322.00 | |||
CD33 Antibody (E-6): m-IgG Fc BP-HRP Bundle | sc-537977 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD33 Antibody (E-6): m-IgGκ BP-HRP Bundle | sc-535473 | 200 µg Ab; 40 µg BP | $361.00 | |||
CD33 Antibody (E-6): m-IgG1 BP-HRP Bundle | sc-545473 | 200 µg Ab; 20 µg BP | $361.00 |