Cardiotrophin-1 Antibody (AN-B3): sc-9991
- Cardiotrophin-1 Antibody (AN-B3) is a mouse monoclonal IgG2a κ Cardiotrophin-1 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against full length Cardiotrophin-1 (CT-1) of human origin
- Cardiotrophin-1 Antibody (AN-B3) is recommended for detection of Cardiotrophin-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Cardiotrophin-1 Antibody (AN-B3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Cardiotrophin-1 Antibody (AN-B3) for WB applications. These reagents are now offered in bundles with Cardiotrophin-1 Antibody (AN-B3) (see ordering information below).
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Cardiotrophin-1 Antibody (AN-B3) is a mouse monoclonal IgG2a kappa light chain antibody that detects Cardiotrophin-1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cardiotrophin-1 monoclonal antibody (AN-B3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cardiotrophin-1 (CT-1) is a crucial member of the interleukin-6 (IL-6) family of cytokines, which play a significant role in cell signaling through gp130 receptor complexes. CT-1 interaction with the leukemia inhibitory factor (LIF) receptor/gp130 complex induces hypertrophy in cardiac myocytes, highlighting CT-1′s role in cardiac health and development. CT-1 is predominantly expressed in the myocardium during cardiogenesis, promoting proliferation and survival of embryonic cardiomyocytes, suggesting CT-1′s vital role in gp130 activation during cardiac development. CT-1 is highly expressed in various tissues, including heart, prostate, ovary, and skeletal muscle, while lower levels are found in lung, kidney, pancreas, thymus, testis, and small intestine, indicating diverse biological functions across different organ systems.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cardiotrophin-1 Antibody (AN-B3) References:
- Molecular cloning and expression of an IL-6 signal transducer, gp130. | Hibi, M., et al. 1990. Cell. 63: 1149-57. PMID: 2261637
- Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy. | Pennica, D., et al. 1995. Proc Natl Acad Sci U S A. 92: 1142-6. PMID: 7862649
- cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of CT-1 gene in ventricle of genetically hypertensive rats. | Ishikawa, M., et al. 1996. Biochem Biophys Res Commun. 219: 377-81. PMID: 8604995
- Human cardiotrophin-1: protein and gene structure, biological and binding activities, and chromosomal localization. | Pennica, D., et al. 1996. Cytokine. 8: 183-9. PMID: 8833032
- Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development. | Wollert, KC. and Chien, KR. 1997. J Mol Med (Berl). 75: 492-501. PMID: 9253712
- Update of gp130 cytokines in multiple myeloma. | Klein, B. 1998. Curr Opin Hematol. 5: 186-91. PMID: 9664158
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cardiotrophin-1 Antibody (AN-B3) | sc-9991 | 200 µg/ml | $322.00 | |||
Cardiotrophin-1 Antibody (AN-B3): m-IgG Fc BP-HRP Bundle | sc-525456 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cardiotrophin-1 Antibody (AN-B3): m-IgG2a BP-HRP Bundle | sc-546266 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cardiotrophin-1 Antibody (AN-B3) AC | sc-9991 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Cardiotrophin-1 Antibody (AN-B3) HRP | sc-9991 HRP | 200 µg/ml | $322.00 | |||
Cardiotrophin-1 Antibody (AN-B3) FITC | sc-9991 FITC | 200 µg/ml | $336.00 | |||
Cardiotrophin-1 Antibody (AN-B3) PE | sc-9991 PE | 200 µg/ml | $349.00 | |||
Cardiotrophin-1 Antibody (AN-B3) Alexa Fluor® 488 | sc-9991 AF488 | 200 µg/ml | $364.00 | |||
Cardiotrophin-1 Antibody (AN-B3) Alexa Fluor® 546 | sc-9991 AF546 | 200 µg/ml | $364.00 | |||
Cardiotrophin-1 Antibody (AN-B3) Alexa Fluor® 594 | sc-9991 AF594 | 200 µg/ml | $364.00 | |||
Cardiotrophin-1 Antibody (AN-B3) Alexa Fluor® 647 | sc-9991 AF647 | 200 µg/ml | $364.00 | |||
Cardiotrophin-1 Antibody (AN-B3) Alexa Fluor® 680 | sc-9991 AF680 | 200 µg/ml | $364.00 | |||
Cardiotrophin-1 Antibody (AN-B3) Alexa Fluor® 790 | sc-9991 AF790 | 200 µg/ml | $364.00 |