ATP5A Antibody (51): sc-136178

ATP5A Antibody (51) is a mouse monoclonal IgG2a kappa light chain antibody that detects ATP5A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-ATP5A antibody (51) is available as the non-conjugated format. ATP5A protein plays a crucial role in cellular energy metabolism as a key component of mitochondrial ATP synthase, which synthesizes adenosine triphosphate (ATP) through oxidative phosphorylation. This process provides energy necessary for various cellular functions, including muscle contraction, nerve impulse propagation, and biosynthetic reactions. ATP5A protein is located in the inner mitochondrial membrane, forming part of the F1F0 ATP synthase complex, consisting of the F1 catalytic core and F0 membrane channel. The F1 component contains three alpha and three beta subunits, along with additional regulatory chains, while F0 component comprises three subunits: a, b, and c. Proper functioning of ATP5A is essential for maintaining the electrochemical gradient across the mitochondrial membrane, which is critical for ATP production. Disruptions in ATP5A function can lead to various metabolic disorders, highlighting ATP5A′s importance in cellular energy homeostasis.

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ATP5A Antibody (51) References:

1. Association of ATP synthase alpha-chain with neurofibrillary degeneration in Alzheimer's disease.  |  Sergeant, N., et al. 2003. Neuroscience. 117: 293-303. PMID: 12614671
2. Nucleotide sequence of a cDNA for the alpha subunit of human mitochondrial ATP synthase.  |  Kataoka, H. and Biswas, C. 1991. Biochim Biophys Acta. 1089: 393-5. PMID: 1830491
3. β-amyloid peptide binds and regulates ectopic ATP synthase α-chain on neural surface.  |  Xing, SL., et al. 2012. Int J Neurosci. 122: 290-7. PMID: 22185089
4. Primary structure and subunit stoichiometry of F1-ATPase from bovine mitochondria.  |  Walker, JE., et al. 1985. J Mol Biol. 184: 677-701. PMID: 2864455
5. RGS12 is required for the maintenance of mitochondrial function during skeletal development.  |  Yuan, G., et al. 2020. Cell Discov. 6: 59. PMID: 32922858
6. Micropeptide ASAP encoded by LINC00467 promotes colorectal cancer progression by directly modulating ATP synthase activity.  |  Ge, Q., et al. 2021. J Clin Invest. 131: PMID: 34591791
7. TNK2/ACK1-mediated phosphorylation of ATP5F1A (ATP synthase F1 subunit alpha) selectively augments survival of prostate cancer while engendering mitochondrial vulnerability.  |  Chouhan, S., et al. 2023. Autophagy. 19: 1000-1025. PMID: 35895804
8. MTA1, a Novel ATP Synthase Complex Modulator, Enhances Colon Cancer Liver Metastasis by Driving Mitochondrial Metabolism Reprogramming.  |  Wang, T., et al. 2023. Adv Sci (Weinh). 10: e2300756. PMID: 37442756
9. Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A.  |  Yin, Z., et al. 2023. Biomed Pharmacother. 166: 115228. PMID: 37557013
10. Proteomic analyses identify HK1 and ATP5A to be overexpressed in distant metastases of lung adenocarcinomas compared to matched primary tumors.  |  Pasternack, H., et al. 2023. Sci Rep. 13: 20948. PMID: 38016997
11. The crystal structure of the nucleotide-free alpha 3 beta 3 subcomplex of F1-ATPase from the thermophilic Bacillus PS3 is a symmetric trimer.  |  Shirakihara, Y., et al. 1997. Structure. 5: 825-36. PMID: 9261073
12. Comparative genomic hybridization analysis of Y79 and FISH mapping indicate the amplified human mitochondrial ATP synthase alpha-subunit gene (ATP5A) maps to chromosome 18q12-->q21.  |  Godbout, R., et al. 1997. Cytogenet Cell Genet. 77: 253-6. PMID: 9284928

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ATP5A Antibody (51) has 40 citations in a variety of scientific publications.

Primary antibodies like Anti-ATP5A Antibody (51) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ATP5A Antibody (51) Specifications

Alternate Product Name: ATP5A

Product Clone Name: 51

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 113-220

Epitope Target: ATP5A

Epitope Species: human

Product Reactivity/Detection: ATP5A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine

Additional Non-Mammalian Reactivity: Arabidopsis thaliana

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 40 citations in various scientific publications

Available Conjugates/Forms for ATP5A Antibody (51): N/A