The chemical class known as ATP5A inhibitors represents a specific group of compounds meticulously designed to modulate the activity of ATP synthase subunit alpha (ATP5A), an integral component of the mitochondrial ATP synthase complex. ATP synthase is a vital enzyme complex responsible for generating adenosine triphosphate (ATP), the universal cellular energy currency. The principal mechanism underlying ATP5A inhibitors involves their targeted interaction with the ATP5A subunit, thereby disrupting or altering its role within the ATP synthase complex. This interaction can influence the efficiency of ATP production and cellular energy metabolism.
Structurally, members of the ATP5A inhibitors chemical class may share distinctive features that allow them to interact specifically with the ATP5A subunit, affecting its function. By interfering with ATP5A, these inhibitors can modulate the intricate process of ATP synthesis and impact cellular energy levels. The exploration of ATP5A inhibitors is a significant avenue of scientific inquiry, offering insights into the complex interplay of molecular components that drive cellular energy production. Through rigorous research and experimentation, scientists strive to uncover the nuances of ATP5A inhibition and its potential implications for cellular metabolism, while contributing to our broader understanding of the fundamental processes that sustain life.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
A natural product, oligomycin A is a well-known inhibitor of mitochondrial ATP synthase, including its ATP5A subunit. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
While primarily known as a complex I inhibitor in the electron transport chain, rotenone can also indirectly affect ATP5A by altering mitochondrial function. | ||||||
TMCB | 905105-89-7 | sc-361383 sc-361383A | 10 mg 50 mg | $135.00 $557.00 | ||
Tetramethylcyclopropyl analogue (TMCB) compounds have been investigated for their potential as ATP synthase inhibitors, including ATP5A. | ||||||
3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine | 195055-03-9 | sc-498264 | 10 mg | $380.00 | ||
An investigational compound, also called R121919, has been studied for its potential to inhibit ATP synthase, including ATP5A. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a natural polyphenol, has been investigated for its effects on mitochondrial function, which may include modulation of ATP5A. | ||||||
Cercosporamide | 131436-22-1 | sc-202095 sc-202095A | 500 µg 2.5 mg | $306.00 $1224.00 | 2 | |
This natural compound has shown potential as an inhibitor of ATP synthase activity, including ATP5A. | ||||||