Date published: 2026-1-9

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ATP5A Inhibitors

The chemical class known as ATP5A inhibitors represents a specific group of compounds meticulously designed to modulate the activity of ATP synthase subunit alpha (ATP5A), an integral component of the mitochondrial ATP synthase complex. ATP synthase is a vital enzyme complex responsible for generating adenosine triphosphate (ATP), the universal cellular energy currency. The principal mechanism underlying ATP5A inhibitors involves their targeted interaction with the ATP5A subunit, thereby disrupting or altering its role within the ATP synthase complex. This interaction can influence the efficiency of ATP production and cellular energy metabolism.

Structurally, members of the ATP5A inhibitors chemical class may share distinctive features that allow them to interact specifically with the ATP5A subunit, affecting its function. By interfering with ATP5A, these inhibitors can modulate the intricate process of ATP synthesis and impact cellular energy levels. The exploration of ATP5A inhibitors is a significant avenue of scientific inquiry, offering insights into the complex interplay of molecular components that drive cellular energy production. Through rigorous research and experimentation, scientists strive to uncover the nuances of ATP5A inhibition and its potential implications for cellular metabolism, while contributing to our broader understanding of the fundamental processes that sustain life.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Oligomycin A

579-13-5sc-201551
sc-201551A
sc-201551B
sc-201551C
sc-201551D
5 mg
25 mg
100 mg
500 mg
1 g
$179.00
$612.00
$1203.00
$5202.00
$9364.00
26
(1)

A natural product, oligomycin A is a well-known inhibitor of mitochondrial ATP synthase, including its ATP5A subunit.

Rotenone

83-79-4sc-203242
sc-203242A
1 g
5 g
$89.00
$259.00
41
(1)

While primarily known as a complex I inhibitor in the electron transport chain, rotenone can also indirectly affect ATP5A by altering mitochondrial function.

TMCB

905105-89-7sc-361383
sc-361383A
10 mg
50 mg
$135.00
$557.00
(0)

Tetramethylcyclopropyl analogue (TMCB) compounds have been investigated for their potential as ATP synthase inhibitors, including ATP5A.

3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine

195055-03-9sc-498264
10 mg
$380.00
(0)

An investigational compound, also called R121919, has been studied for its potential to inhibit ATP synthase, including ATP5A.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol, a natural polyphenol, has been investigated for its effects on mitochondrial function, which may include modulation of ATP5A.

Cercosporamide

131436-22-1sc-202095
sc-202095A
500 µg
2.5 mg
$306.00
$1224.00
2
(1)

This natural compound has shown potential as an inhibitor of ATP synthase activity, including ATP5A.