ALK-1 Antibody (E-11): sc-518147
- ALK-1 Antibody (E-11) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 55-73 of ALK-1 of human origin
- recommended for detection of ALK-1 of human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for ALK-1 Antibody (E-11) for WB applications. This reagent is now offered in a bundle with ALK-1 Antibody (E-11) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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ALK-1 Antibody (E-11) is a mouse monoclonal IgM antibody that detects ALK-1 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ALK-1, also known as activin receptor-like kinase 1, plays a crucial role in the regulation of vascular development and homeostasis, making ALK-1 essential for maintaining normal blood vessel function. ALK-1 is primarily located on the surface of vascular endothelial cells, where ALK-1 mediates signaling pathways that influence angiogenesis and vascular remodeling. Proper functioning of ALK-1 is vital, as mutations in ALK-1 are implicated in hereditary hemorrhagic telangiectasia (HHT), a disorder characterized by abnormal blood vessel formation and increased risk of bleeding. By understanding the localization and function of ALK-1, researchers can better comprehend ALK-1′s role in vascular diseases and explore potential therapeutic targets. Anti-ALK-1 antibody (E-11) is an invaluable tool for studying this important protein and its implications in human health.
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ALK-1 Antibody (E-11) References:
- Primary anaplastic large cell lymphoma of the central nervous system: prognostic effect of ALK-1 expression. | George, DH., et al. 2003. Am J Surg Pathol. 27: 487-93. PMID: 12657933
- ALK1 as an emerging target for antiangiogenic therapy of cancer. | Cunha, SI. and Pietras, K. 2011. Blood. 117: 6999-7006. PMID: 21467543
- Differential signalling through ALK-1 and ALK-5 regulates leptin expression in mesenchymal stem cells. | Zeddou, M., et al. 2012. Stem Cells Dev. 21: 1948-55. PMID: 22087763
- BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells. | Tao, B., et al. 2020. J Biol Chem. 295: 18179-18188. PMID: 33097593
- OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin. | Fu, Y., et al. 2021. Mol Cell. 81: 3187-3204.e7. PMID: 34157307
- ALK1 signaling is required for the homeostasis of Kupffer cells and prevention of bacterial infection. | Zhao, D., et al. 2022. J Clin Invest. 132: PMID: 34874921
- The ALK1‑Smad1/5‑ID1 pathway participates in tumour angiogenesis induced by low‑dose photodynamic therapy. | Guo, X., et al. 2023. Int J Oncol. 62: PMID: 36928315
- Endothelial cell SMAD6 balances Alk1 function to regulate adherens junctions and hepatic vascular development. | Kulikauskas, MR., et al. 2023. Development. 150: PMID: 37787089
- Evaluation of Immunohistochemical Expression of ALK-1 in Gliomas, WHO Grade 4 and Its Correlation with IDH1-R132H Mutation Status. | Khairy, RA., et al. 2024. Asian Pac J Cancer Prev. 25: 317-323. PMID: 38285799
- Elevated circulating BMP9 aggravates pulmonary angiogenesis in hepatopulmonary syndrome rats through ALK1-Endoglin-Smad1/5/9 signalling. | Yang, C., et al. 2024. Eur J Clin Invest. 54: e14212. PMID: 38591651
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ALK-1 Antibody (E-11) | sc-518147 | 200 µg/ml | $322.00 | |||
ALK-1 Antibody (E-11): m-IgGκ BP-HRP Bundle | sc-551132 | 200 µg Ab; 40 µg BP | $361.00 |