Adenosine A2A-R Antibody (5H30): sc-70321

Adenosine A2A-R Antibody (5H30) is a mouse monoclonal IgG2a antibody that detects Adenosine A2A-R in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Adenosine A2A-R is a critical member of the G protein-coupled receptor family, playing a vital role in mediating physiological responses such as coronary vasodilation and inflammatory process modulation. Adenosine A2A-R is predominantly located on the cell membrane, where Adenosine A2A-R interacts with extracellular adenosine, leading to intracellular signaling pathway activation that regulates vascular tone and immune responses. Proper functioning of Adenosine A2A-R is essential for maintaining cardiovascular health and modulating inflammation, making Adenosine A2A-R a significant target for therapeutic interventions in conditions such as heart disease and autoimmune disorders. Additionally, Adenosine A2A-R′s ability to inhibit pro-inflammatory cytokine production highlights Adenosine A2A-R′s importance in controlling excessive immune responses, further underscoring Adenosine A2A-R′s relevance in both health and disease. With robust reactivity and versatility in various applications, anti-Adenosine A2A-R antibody (5H30) serves as an invaluable tool for researchers investigating adenosine signaling roles in biological systems.

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Adenosine A2A-R Antibody (5H30) References:

1. Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB.  |  Wiese, S., et al. 2007. Proc Natl Acad Sci U S A. 104: 17210-5. PMID: 17940030
2. A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R.  |  Borroto-Escuela, DO., et al. 2010. Biochem Biophys Res Commun. 394: 222-7. PMID: 20197060
3. Dendritic cells tolerized with adenosine A₂AR agonist attenuate acute kidney injury.  |  Li, L., et al. 2012. J Clin Invest. 122: 3931-42. PMID: 23093781
4. A critical role of striatal A2A R-mGlu5 R interactions in modulating the psychomotor and drug-seeking effects of methamphetamine.  |  Wright, SR., et al. 2016. Addict Biol. 21: 811-25. PMID: 25975203
5. Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure.  |  Madeira, MH., et al. 2015. J Neuroinflammation. 12: 115. PMID: 26054642
6. Sesamin protects against renal ischemia reperfusion injury by promoting CD39-adenosine-A2AR signal pathway in mice.  |  Li, K., et al. 2016. Am J Transl Res. 8: 2245-54. PMID: 27347331
7. Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation.  |  Borroto-Escuela, DO., et al. 2018. Front Neurosci. 12: 43. PMID: 29467608
8. A macrophage membrane-coated mesoporous silica nanoplatform inhibiting adenosine A2AR via in situ oxygen supply for immunotherapy.  |  Wen, X., et al. 2023. J Control Release. 353: 535-548. PMID: 36481693
9. ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma.  |  Ran, L., et al. 2023. Sci Rep. 13: 19477. PMID: 37945707
10. ADORA2A-driven proline synthesis triggers epigenetic reprogramming in neuroendocrine prostate and lung cancers.  |  Jing, N., et al. 2023. J Clin Invest. 133: PMID: 38099497

The preferred Adenosine A2A-R antibody is Adenosine A2A-R Antibody (7F6-G5-A2): sc-32261.