ACTR-IIA Antibody (D-9): sc-515826

ACTR-IIA Antibody (D-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects ACTR-IIA protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-ACTR-IIA antibody (D-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ACTR-IIA protein, also known as ACVR2A, plays a crucial role in the transforming growth factor β signaling pathway, which regulates various cellular processes such as gene expression, cell differentiation, and morphogenesis. Located primarily in the cell membrane, ACTR-IIA interacts with type I receptors to form a heteromeric complex that transmits signals from ligands like activin. Such interaction is particularly important in the brain, where both receptor types are highly expressed, influencing neural development and function. ACTR-IIA′s ability to mediate distinct biological effects in a dose-dependent manner underscores its significance in developmental biology and potential implications in various diseases, making ACTR-IIA (D-9) monoclonal antibody an invaluable tool for researchers studying these pathways.

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ACTR-IIA Antibody (D-9) References:

1. A short loop on the ALK-2 and ALK-4 activin receptors regulates signaling specificity but cannot account for all their effects on early Xenopus development.  |  Armes, NA., et al. 1999. J Biol Chem. 274: 7929-35. PMID: 10075688
2. A miR-590/Acvr2a/Rad51b axis regulates DNA damage repair during mESC proliferation.  |  Liu, Q., et al. 2014. Stem Cell Reports. 3: 1103-17. PMID: 25458897
3. ACVR2A promoter polymorphism rs1424954 in the Activin-A signaling pathway in trophoblasts.  |  Thulluru, HK., et al. 2015. Placenta. 36: 345-9. PMID: 25659497
4. Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis.  |  Monsivais, D., et al. 2021. Nat Commun. 12: 3386. PMID: 34099644
5. CircRNA ACVR2A Sponges miR-1290 to Modulate Cell Progression in Gastric Cancer.  |  Zhuang, Y., et al. 2022. J Oncol. 2022: 9461054. PMID: 35186081
6. Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2.  |  Zhang, H., et al. 2023. Mol Carcinog. 62: 1585-1598. PMID: 37378449
7. Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway.  |  Fei, D., et al. 2024. Mol Cancer. 23: 159. PMID: 39107843
8. Cloning and characterization of a human type II receptor for bone morphogenetic proteins.  |  Rosenzweig, BL., et al. 1995. Proc Natl Acad Sci U S A. 92: 7632-6. PMID: 7644468
9. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.  |  Cárcamo, J., et al. 1994. Mol Cell Biol. 14: 3810-21. PMID: 8196624
10. Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors.  |  Attisano, L., et al. 1993. Cell. 75: 671-80. PMID: 8242742
11. The ALK-2 and ALK-4 activin receptors transduce distinct mesoderm-inducing signals during early Xenopus development but do not co-operate to establish thresholds.  |  Armes, NA. and Smith, JC. 1997. Development. 124: 3797-804. PMID: 9367435
12. Bone morphogenetic proteins and their receptors: potential functions in the brain.  |  Ebendal, T., et al. 1998. J Neurosci Res. 51: 139-46. PMID: 9469567

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ACTR-IIA Antibody (D-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ACTR-IIA Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ACTR-IIA Antibody (D-9) Specifications

Alternate Product Name: ACTR-IIA

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 114-135

Epitope Target: ACTR-IIA

Epitope Species: human

Product Reactivity/Detection: ACTR-IIA

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ACTR-IIA Antibody (D-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred ACTR-II antibody is ACTR-II Antibody (F-12): sc-390977.