Date published: 2026-7-20

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XBP Antibodies

Santa Cruz Biotechnology features a diverse variety of XBP Antibodies for advanced research in cellular stress responses and the unfolded protein response (UPR). XBP Antibodies are validated for western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). XBP, or X-box binding protein, plays a central role in regulating gene expression during the UPR, which is essential for maintaining cellular homeostasis under stress conditions. The activation of XBP is crucial for proper protein folding and the overall health of the endoplasmic reticulum. Dysregulation of XBP has been linked to various diseases, including cancer and neurodegenerative disorders, making it significant in both basic and translational research. Understanding XBP function helps reveal key mechanisms in cellular stress pathways and protein quality control. Investigating XBP signaling pathways provides insights into potential therapeutic targets for various diseases. Research with XBP can enhance understanding of cellular adaptation to stress conditions. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing scientific knowledge of cellular stress responses and therapeutic development.

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XBP Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

XBP1 Antibody (F-4)

sc-8015mouse IgG1 κ76-263 (m)WB, IP, IF, ELISAm, r, h
62
(27)

XBP siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

XBP1 siRNA (h)

sc-38627hGene SilencingN/A
35
(1)

XBP1 shRNA Plasmid (h)

sc-38627-SHhGene SilencingPuromycin
35
(1)

XBP1 shRNA (h) Lentiviral Particles

sc-38627-VhGene SilencingPuromycin
35
(1)

XBP1 siRNA (m)

sc-38628mGene SilencingN/A
9
(0)

XBP1 shRNA Plasmid (m)

sc-38628-SHmGene SilencingPuromycin
9
(0)

XBP1 shRNA (m) Lentiviral Particles

sc-38628-VmGene SilencingPuromycin
9
(0)

XBP CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

XBP1 CRISPR/Cas9 KO Plasmid (h2)

sc-400131-KO-2Gene Knockouth0
(0)

XBP1 HDR Plasmid (h2)

sc-400131-HDR-2Homology Directed Repairh0
(0)

XBP1 CRISPR/Cas9 KO Plasmid (m)

sc-423727Gene Knockoutm0
(1)

XBP1 HDR Plasmid (m)

sc-423727-HDRHomology Directed Repairm0
(1)

XBP CRISPR Double Nickase Plasmids

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XBP1 Double Nickase Plasmid (h)

sc-400131-NICGene Knockouth0
(0)

XBP1 Double Nickase Plasmid (h2)

sc-400131-NIC-2Gene Knockouth0
(0)

XBP1 Double Nickase Plasmid (m)

sc-423727-NICGene Knockoutm0
(0)

XBP1 Double Nickase Plasmid (m2)

sc-423727-NIC-2Gene Knockoutm0
(0)

XBP CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

XBP1 CRISPR Activation Plasmid (h)

sc-400131-ACTGene Activationh0
(0)

XBP1 CRISPR Activation Plasmid (m)

sc-423727-ACTGene Activationm0
(0)

XBP1 CRISPR Activation Plasmid (m2)

sc-423727-ACT-2Gene Activationm0
(0)

XBP1 Lentiviral Activation Particles (m)

sc-423727-LACGene Activationm0
(0)