RecQL1 Activators
The chemical class known as RecQL1 activators encompasses a variety of compounds that directly or indirectly influence the activity of the DNA helicase RecQL1, a crucial player in DNA metabolism and maintenance. Among these activators, ML216, NSC 19630, and RK-33 serve as direct inhibitors of RecQL1 helicase activity, directly interfering with its catalytic function in unwinding DNA strands. These compounds provide a specific and direct means of modulating RecQL1 activity by directly interacting with its helicase domain. Additionally, compounds like Novobiocin, Quercetin, and 8-Methoxypsoralen act as indirect modulators of RecQL1. Novobiocin affects DNA gyrase and general DNA processing enzymes, indirectly influencing RecQL1 by altering DNA topology. Quercetin, a flavonoid, directly inhibits RecQ helicases, including RecQL1, interfering with its helicase activity and DNA unwinding capabilities. 8-Methoxypsoralen, a DNA intercalator, indirectly influences RecQL1 by altering DNA structure and substrate accessibility.
Compounds such as Ellipticine, Curcumin, and Mitoxantrone provide indirect means of modulating RecQL1 function. Ellipticine, a DNA intercalator and topoisomerase inhibitor, indirectly influences RecQL1 by altering overall DNA processing environments. Curcumin, a natural compound, has diverse effects on cellular pathways, impacting DNA repair and cell cycle regulation, indirectly influencing RecQL1. Mitoxantrone, a topoisomerase II inhibitor, indirectly modulates RecQL1 by affecting DNA topology and processing. RHPS4 and Camptothecin act as indirect modulators of RecQL1 by stabilizing G-quadruplex structures and inhibiting topoisomerase I, respectively. These compounds alter DNA structures and processing environments, providing indirect means of modulating RecQL1 activity. The RecQL1 activators offer a comprehensive view of the diverse strategies, both direct and indirect, for modulating the function of RecQL1 in DNA metabolism and maintenance. The chemical class provides valuable tools for studying RecQL1 and understanding its intricate role in cellular processes related to DNA stability and repair.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid compound that exhibits inhibitory effects on RecQ helicases, including RecQL1. By interfering with the helicase activity, Quercetin serves as a potential direct modulator of RecQL1 function. This compound disrupts the unwinding of DNA strands by RecQL1, offering a direct means of influencing its catalytic activity and involvement in DNA metabolism. | ||||||
Methoxsalen (8-Methoxypsoralen) | 298-81-7 | sc-200505 | 1 g | $28.00 | 1 | |
8-Methoxypsoralen is a DNA intercalator that can indirectly influence RecQL1 function. While not specific to RecQL1, this compound intercalates into DNA, potentially affecting the substrate accessibility for RecQL1. By altering DNA structure, 8-Methoxypsoralen provides an indirect means of modulating RecQL1 activity, impacting its ability to unwind DNA strands and participate in DNA metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural compound with anti-cancer properties. It can indirectly modulate RecQL1 function by affecting multiple cellular pathways. Curcumin's diverse effects include modulation of DNA repair and cell cycle regulation, providing indirect means of influencing RecQL1 activity. While not a specific inhibitor, Curcumin alters the cellular environment, potentially impacting RecQL1's role in DNA metabolism. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $285.00 | 8 | |
Mitoxantrone is a topoisomerase II inhibitor that indirectly influences RecQL1 function. By inhibiting topoisomerase II, Mitoxantrone can alter DNA topology and processing, indirectly modulating the substrate accessibility for RecQL1. This compound provides an indirect means of modulating RecQL1 activity by affecting the overall DNA processing environment and influencing RecQL1's participation in DNA metabolism. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that indirectly affects RecQL1 function. By inhibiting topoisomerase I, Camptothecin induces DNA damage and alters DNA topology, indirectly modulating the substrate accessibility for RecQL1. This compound provides an indirect means of influencing RecQL1 activity by affecting the overall DNA processing environment and impacting RecQL1's participation in DNA metabolism. | ||||||
Thymoquinone | 490-91-5 | sc-215986 sc-215986A | 1 g 5 g | $47.00 $133.00 | 21 | |
Thymoquinone is a bioactive compound with anti-cancer properties. While not specific to RecQL1, it can indirectly influence RecQL1 function by affecting cellular pathways. Thymoquinone's diverse effects include modulation of DNA repair and cell cycle regulation, providing indirect means of influencing RecQL1 activity. While not a specific inhibitor, Thymoquinone alters the cellular environment, potentially impacting RecQL1's role in DNA metabolism. | ||||||