Myosin IXa Activators
Myosin IXa is a protein encoded by the MYO9A gene in humans. It belongs to the myosin superfamily, a diverse group of motor proteins known for their roles in muscle contraction and a wide variety of other cellular processes. Myosin IXa is considered an unconventional myosin due to its unique structure and function compared to the more well-known muscle myosins.Structurally, Myosin IXa contains a motor domain that can bind ATP and actin, a regulatory domain, and a tail domain. Uniquely, the tail domain has a RhoGAP domain, which can negatively regulate small GTPases, particularly Rho-type GTPases. These GTPases control a variety of cellular processes, including cytoskeletal dynamics and cell migration.
Functionally, Myosin IXa is involved in actin-based intracellular transport and cell motility. By interacting with the actin cytoskeleton, it plays a critical role in maintaining cell shape and polarity. It also contributes to intracellular signal transduction through its RhoGAP activity.Moreover, Myosin IXa is implicated in the regulation of cell adhesion, contributing to processes such as wound healing and immune response. It also plays a role in the development of neuronal cells and may be involved in the formation of dendritic spines, which are small protrusions on neurons involved in transmitting synaptic signals.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Blebbistatin, an inhibitor of myosin II, can alter cytoskeletal dynamics, potentially influencing Myosin IXa activity indirectly. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632, a ROCK inhibitor, affects actin cytoskeleton organization, which might have an indirect effect on Myosin IXa function. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7, an inhibitor of myosin light chain kinase, can modulate actin-myosin interaction, potentially impacting Myosin IXa activity. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D, an inhibitor of actin polymerization, can alter cytoskeletal dynamics, potentially affecting Myosin IXa function. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide, an actin-stabilizing agent, might indirectly influence Myosin IXa through its effects on the actin cytoskeleton. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A, an actin-disrupting agent, can impact actin dynamics, potentially influencing Myosin IXa activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels, which may indirectly influence Myosin IXa. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, a phosphatase inhibitor, can affect phosphorylation states within the cell, potentially impacting Myosin IXa activity. | ||||||