Gm410 Inibitori

I comuni inibitori di Gm410 includono, ma non solo, Bortezomib CAS 179324-69-7, MG-132 [Z-Leu- Leu-Leu-CHO] CAS 133407-82-6, Lactacystin CAS 133343-34-7, Withaferin A CAS 5119-48-2 e Curcumin CAS 458-37-7.

Ankub1 inhibitors include molecules that can indirectly influence Ankub1 activity through interference with the ubiquitin-proteasome system or by affecting the stability and interactions of proteins with ankyrin repeats. These compounds can increase cellular levels of ubiquitinated proteins by inhibiting the proteasome, as seen with Bortezomib, MG132, Lactacystin, Withaferin A, and Epoxomicin. This inhibition can lead to an accumulation of proteins that are substrates for Ankub1, potentially saturating the ubiquitination mechanism and indirectly reducing the functional activity of Ankub1.

Other compounds in this class, such as PYR-41 and MLN4924, target components upstream of the ubiquitination cascade. PYR-41 hinders ubiquitin activating enzyme E1, which is critical for the initial steps of ubiquitination that Ankub1 could catalyze or facilitate. MLN4924 inhibits the activating enzyme NEDD8, affecting cullin-RING ubiquitin ligase complexes, which may alter the ubiquitination landscape in which Ankub1 operates. In addition, compounds such as P22077 and IU1 inhibit specific deubiquitinating enzymes, which may result in altered ubiquitin dynamics and affect the turnover of Ankub1 substrates. Curcumin is known for its broad modulatory effects on protein interactions and signaling pathways, which could have downstream effects on the role of Ankub1 in the cell.