Molecular structure of IU1, CAS Number: 314245-33-5
IU1 (CAS 314245-33-5)
See product citations (2)
Alternate Names:
1-(1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(pyrrolidin-1-yl)ethanone
Application:
IU1 is an inhibitor of Usp14 which prevents catalytic activity of Usp14
CAS Number:
314245-33-5
Purity:
≥98%
Molecular Weight:
300.37
Molecular Formula:
C18H21FN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
IU1 is a small molecule inhibitor that functions by targeting and inhibiting the deubiquitinating enzyme USP14. By binding to the active site of USP14, IU1 disrupts the enzyme′s ability to cleave ubiquitin chains from protein substrates, leading to the accumulation of ubiquitinated proteins. This accumulation ultimately results in the activation of the proteasome, the cellular machinery responsible for degrading unwanted or damaged proteins. In this way, IU1 indirectly promotes the degradation of ubiquitinated proteins by the proteasome, thereby influencing cellular protein homeostasis. This mechanism of action makes IU1 useful in studying the role of USP14 and the proteasome in cellular processes and may have implications for understanding protein degradation pathways in various experimental applications.
IU1 (CAS 314245-33-5) References
- USP14 inhibitor IU1 prevents ventilator-induced lung injury in rats. | Xu, YH. and Guo, NL. 2014. Cell Mol Biol (Noisy-le-grand). 60: 50-4. PMID: 25198582
- USP14 inhibitor attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice. | Min, JW., et al. 2017. J Neurochem. 140: 826-833. PMID: 28029679
- An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. | Boselli, M., et al. 2017. J Biol Chem. 292: 19209-19225. PMID: 28972160
- Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. | Wang, Y., et al. 2018. Cell Res. 28: 1186-1194. PMID: 30254335
- USP14 promotes K63-linked RIG-I deubiquitination and suppresses antiviral immune responses. | Li, H., et al. 2019. Eur J Immunol. 49: 42-53. PMID: 30466171
- M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124. | Song, Y., et al. 2019. Theranostics. 9: 2910-2923. PMID: 31244932
- IU1 suppresses proliferation of cervical cancer cells through MDM2 degradation. | Xu, L., et al. 2020. Int J Biol Sci. 16: 2951-2963. PMID: 33061808
- Discovery of new promising USP14 inhibitors: computational evaluation of the thumb-palm pocket. | Adelakun, N., et al. 2022. J Biomol Struct Dyn. 40: 3060-3070. PMID: 33170088
- Small-Molecule Inhibitors Targeting Proteasome-Associated Deubiquitinases. | Moon, S., et al. 2021. Int J Mol Sci. 22: PMID: 34207520
- USP14 maintains HIF1-α stabilization via its deubiquitination activity in hepatocellular carcinoma. | Lv, C., et al. 2021. Cell Death Dis. 12: 803. PMID: 34420039
- A self-amplifying USP14-TAZ loop drives the progression and liver metastasis of pancreatic ductal adenocarcinoma. | Zhao, C., et al. 2023. Cell Death Differ. 30: 1-15. PMID: 35906484
- Inhibition of USP14 Suppresses ROS-dependent Ferroptosis and Alleviates Renal Ischemia/Reperfusion Injury. | Pan, J., et al. 2023. Cell Biochem Biophys. 81: 87-96. PMID: 36255562
- USP14 inhibition promotes recovery by protecting BBB integrity and attenuating neuroinflammation in MCAO mice. | Hou, W., et al. 2023. CNS Neurosci Ther.. PMID: 37269080
Inhibitor of:
3BP2, 4930524E20Rik, 4931431F19Rik, ADRM1, APC11, APC2, ARIH1, ASXL2, BTBD2, BTBD6, CCP6, DUB1, DUB1A, DUB2, DUB2A, EG368203, EG665802, EULIR, FAM63A, FBXW2, G2E3, Gm410, HAUSP, HECTD2, HECTD3, KBTBD5, KLHDC2, LOC728393, LRSAM1, NEDL1, Nulp1, OTUB1, OTUD1, OTUD2, OTUD3, OTUD4, OTUD5, OTUD7A, OTUD7B, PLIC-1, PSMD2, Rfp2, RING1B, RLIM, RMND5B, RNF113A, RNF113A1, RNF138, RNF145, RNF151, RNF214, RNF222, RNF32, RNF39, RNF44, Rsp5, Rub1, STAMBP, TRIM41, UBC, UBC2, UBE2H, UBE2J1, UBE2QL1, UBE2Z, Ubp-M, Ubr1, UBTD2, UBXN2B, UCH-L1, UCH-L3, UCH-L4, UCH-L5, UFD1, USP14, USP15, USP17L, USP20, USP26, USP3, USP32, USP35, USP37, USP4, USP44, USP48, USP50, USP52, USP6, and ZFAND2B.Activator of:
ASB-13, ASB-17, ASB-5, C19orf62_5430437P03Rik, CUL-7, DUB1A, DUB2, ECM29, EG368203, Fbxo12J, FBXO39, FBXO4, Gm514, KLHL10, KLHL11, KLHL24, KLHL36, KLHL4, KLHL5, OTUD4, Rbx2, RNF149, Rpn11, UBC2, UBE2D4, UBE2QL1, UBE2Z, UBE4A, UBL5, UBPY, UCH-L4, USP10, USP17L29, USP17L4, USP17L7, USP17L8, USP25, USP31, USP47, and USP54.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IU1, 10 mg | sc-361215 | 10 mg | $138.00 | |||
IU1, 50 mg | sc-361215A | 50 mg | $607.00 | |||
IU1, 100 mg | sc-361215B | 100 mg | $866.00 |