eIF3α Activators
eIF3α activators are a specific class of chemicals that target and influence the activity of the eukaryotic initiation factor 3 subunit alpha (eIF3α), which is a critical component of the eIF3 complex involved in the initiation phase of protein synthesis. The eIF3 complex is one of the largest and most essential multiprotein complexes required for the assembly of the 40S ribosomal subunit with the messenger RNA (mRNA) and the initiation tRNA, thereby facilitating the accurate and efficient initiation of translation.
Direct activators of eIF3α engage with the protein in a manner that enhances its role in the initiation complex. This could involve binding to eIF3α in such a way that it augments its interaction with other subunits of eIF3 or with the ribosomal 40S subunit. It might also promote the interaction of eIF3 with the mRNA's 5' untranslated region, thereby facilitating the ribosome's scanning for the start codon. By stabilizing these interactions, direct activators could increase the efficiency of the translation initiation process, leading to enhanced protein synthesis. Indirect activators of eIF3α might not bind directly to the eIF3α subunit but could modify its activity or abundance through various cellular pathways. These could include upregulation of the expression of the gene encoding eIF3α, post-translational modifications that alter the function or stability of eIF3α, or the modulation of interacting partners that are critical for the eIF3 complex's assembly and function. Such modifications could lead to an increase in the formation of the translation pre-initiation complex and thus, the overall rate of translation initiation in the cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. Inhibition of mTOR can stimulate autophagy and may lead to enhanced translation initiation, as eIF3α is a component of the eIF3 translation initiation complex. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin 1 is an ATP-competitive inhibitor of mTOR. By inhibiting mTOR, Torin 1 can stimulate autophagy and indirectly lead to enhanced translation initiation, as eIF3α is part of the eIF3 translation initiation complex. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin activates AMPK, which can inhibit the mTOR pathway. This inhibition can lead to enhanced translation initiation by potentially upregulating eIF3α, a component of the eIF3 translation initiation complex. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMPK activator. By activating AMPK, which can inhibit the mTOR pathway, AICAR may indirectly lead to increased translation initiation by potentially upregulating eIF3α, a part of the eIF3 translation initiation complex. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound known to activate SIRT1, which can inhibit mTOR. This inhibition may lead to enhanced translation initiation by potentially upregulating eIF3α, a component of the eIF3 translation initiation complex. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid known to activate AMPK, which can inhibit the mTOR pathway. This inhibition may indirectly lead to enhanced translation initiation, as eIF3α is a part of the eIF3 translation initiation complex. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is a plant alkaloid that activates AMPK. Activating AMPK can inhibit the mTOR pathway, potentially leading to enhanced translation initiation, as eIF3α is a part of the eIF3 translation initiation complex. | ||||||
Phenformin Hydrochloride | 834-28-6 | sc-219590 | 10 g | $119.00 | 4 | |
Phenformin is an AMPK activator. By activating AMPK, which can inhibit the mTOR pathway, Phenformin may indirectly lead to increased translation initiation by potentially upregulating eIF3α, a part of the eIF3 translation initiation complex. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
Dorsomorphin is a compound that inhibits AMPK. Inhibition of AMPK can stimulate the mTOR pathway, potentially leading to enhanced translation initiation as eIF3α is a part of the eIF3 translation initiation complex. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $188.00 $327.00 | 1 | |
Perifosine is an alkylphospholipid that activates AMPK. By activating AMPK, which can inhibit the mTOR pathway, Perifosine may indirectly lead to increased translation initiation by potentially upregulating eIF3α, a part of the eIF3 translation initiation complex. | ||||||