EF-1 ε1 Activators
EF-1 ε1 activators are chemical compounds that enhance the function of EF-1 ε1, a protein involved in several cellular processes, including ER stress response and signal transduction of the EGFR and ERK pathways. Rapamycin, Torin 1, and AZD8055 are mTOR inhibitors that can enhance the interaction between EF-1 ε1 and mTOR, thus enhancing the function of EF-1 ε1. Thapsigargin, an inhibitor of the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA), can lead to an increase in cytosolic calcium concentration, which can then lead to activation of PKC known to phosphorylate EF-1 ε1 and enhance its function. Tunicamycin and DTT, inhibitors of N-linked glycosylation and disruptors of disulfide bonds within proteins, respectively, can trigger ER stress and therefore enhance EF-1 ε1 function, as EF-1 ε1 is involved in ER stress responses.
Staurosporine and Go 6983, potent inhibitors of PKCs, can enhance the phosphorylation of EF-1 ε1, further enhancing its function. The role of EF-1 ε1 in the EGFR pathway allows EGF, an activator of the EGFR pathway, and Gefitinib, an EGFR inhibitor, to enhance the function of EF-1 ε1 through the activation and stress response of the EGFR pathway, respectively. Lastly, PD 98059 and U0126, inhibitors of MEK, a component of the ERK pathway, are capable of enhancing EF-1 ε1 function by inducing a stress response in the ERK pathway, a pathway in which EF-1 ε1 is involved.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. EF-1 ε1 is a known interactor of mTOR, and inhibition of mTOR by rapamycin can enhance the interaction between EF-1 ε1 and mTOR, thereby enhancing the function of EF-1 ε1. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin 1 is a potent inhibitor of mTOR. Like Rapamycin, Torin 1 can enhance the interaction between EF-1 ε1 and mTOR, thus enhancing the function of EF-1 ε1. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
AZD8055 is a specific inhibitor of mTOR. It can enhance the function of EF-1 ε1 by enhancing the interaction between EF-1 ε1 and mTOR due to its inhibitory action on mTOR. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is an inhibitor of the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA), leading to an increase in cytosolic calcium concentration. High cytosolic calcium levels can lead to activation of PKC, which is known to phosphorylate EF-1 ε1, thereby enhancing its function. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin is an inhibitor of N-linked glycosylation, which can lead to ER stress. EF-1 ε1 is known to be involved in ER stress responses, and thus, tunicamycin can enhance the function of EF-1 ε1 by triggering ER stress. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a powerful inhibitor of PKCs. Inhibition of PKCs by staurosporine can enhance the phosphorylation of EF-1 ε1, thus enhancing its function. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go 6983 is a broad-spectrum PKC inhibitor. Similar to staurosporine, Go 6983 can enhance the phosphorylation of EF-1 ε1, thereby enhancing its function. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $63.00 $114.00 $218.00 $349.00 | 74 | |
Gefitinib is an EGFR inhibitor. Despite its inhibitory action, gefitinib can enhance EF-1 ε1 function by inducing a stress response in the EGFR pathway, in which EF-1 ε1 is involved. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is an inhibitor of MEK, a component of the ERK pathway. Despite its inhibitory action, PD 98059 can enhance EF-1 ε1 function by inducing a stress response in the ERK pathway, in which EF-1 ε1 is involved. | ||||||