Ciao 1 Activators
Ciao1 Activators are a class of chemical compounds designed to enhance the functional activity of Ciao1, a component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. This complex is crucial for the ubiquitination and subsequent proteasomal degradation of target proteins. Certain compounds like Pyrvinium Pamoate, Indirubin, Niclosamide, and XAV939, exert their effects by influencing the WNT/β-catenin signaling pathway. These compounds play a crucial role in destabilizing β-catenin, a known target of Ciao1-mediated degradation, thus indirectly enhancing the functional activity of Ciao1.
In addition, compounds like Cycloheximide, Quercetin, Wogonin, Genistein, PD98059, SB203580, SP600125, and LY294002 are known to influence protein biosynthesis and degradation, and various signaling pathways. For instance, Cycloheximide, an inhibitor of protein biosynthesis, could potentially enhance the demand for protein degradation, a process in which Ciao1 is directly involved. Similarly, compounds like Quercetin and LY294002, known inhibitors of PI3K, and Wogonin, an inhibitor of STAT3, can indirectly influence protein degradation pathways, and consequently, may enhance the functional activity of Ciao1.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pyrvinium Pamoate | 3546-41-6 | sc-476920A sc-476920 | 250 mg 500 mg | $228.00 $422.00 | ||
Pyrvinium Pamoate inhibits WNT signaling, which may indirectly increase the degradation of β-catenin, a target of the SCF complex that includes Ciao1, thus enhancing its activity. | ||||||
Indirubin | 479-41-4 | sc-201531 sc-201531A | 5 mg 25 mg | $114.00 $525.00 | 4 | |
Indirubin inhibits GSK3β, which could stabilize β-catenin, a target of Ciao1-mediated degradation. This may indirectly increase the activity of Ciao1. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide disrupts WNT/β-catenin signaling, possibly leading to increased degradation of β-catenin, a target of the SCF complex that includes Ciao1. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
XAV939 stabilizes axin by inhibiting tankyrase, leading to increased β-catenin degradation, in which Ciao1 is involved. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits protein biosynthesis, potentially increasing the demand for protein degradation, a process Ciao1 is involved in. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin inhibits PI3K, a kinase that indirectly regulates protein degradation, potentially enhancing Ciao1 activity. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin inhibits STAT3, a protein that indirectly regulates protein degradation, potentially enhancing Ciao1 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein inhibits tyrosine kinases, which can indirectly affect protein degradation pathways and hence may enhance Ciao1 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 inhibits MEK, which can indirectly affect protein degradation pathways and hence may enhance Ciao1 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 inhibits p38 MAPK, which can indirectly affect protein degradation pathways and hence may enhance Ciao1 activity. | ||||||