4933403G14Rik Activators
Chemical activators of microtubule-associated protein 10 (MAP10) operate through various interactions with microtubules, impacting their dynamics and consequently influencing the functional activation of MAP10. Paclitaxel and its synonymous compound Taxol, along with other stabilizing agents like Epothilone B, Peloruside A, Laulimalide, and Discodermolide, promote the assembly of microtubules and enhance their stabilization. This action facilitates the binding of MAP10 to the microtubules, leading to its activation. By preventing microtubule disassembly, these chemicals maintain a state that is conducive to the sustained association of MAP10 with the microtubule network. As MAP10's functionality is closely tied to the integrity of microtubules, the presence of these stabilizing agents ensures that MAP10 can effectively engage with the microtubule structure, thereby realizing its functional potential.
Conversely, chemicals like Nocodazole, Vinblastine, Vincristine, Colchicine, Podophyllotoxin, and 2-Methoxyestradiol initially disrupt microtubule polymerization. However, upon their removal, a rapid repolymerization of microtubules occurs, which leads to a surge in available binding sites for MAP10. This 'rebound' effect results in an increased opportunity for MAP10 to bind to newly polymerized microtubules, facilitating its activation. The transition from a destabilized to a stabilized microtubule environment allows MAP10 to effectively engage with the microtubules as they undergo dynamic changes. The enhanced polymerization post-removal of these depolymerizing agents simulates a scenario where MAP10 can readily associate with microtubules, thus enabling its functional activation in the context of microtubule dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which can enhance the stability and polymerization of microtubules. This stabilization can lead to an increase in microtubule-associated protein 10 (MAP10) binding to microtubules, resulting in its functional activation as MAP10 is known to associate with microtubules. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, and its removal can lead to a 'rebound' effect, where microtubules rapidly repolymerize, potentially increasing the activity of microtubule-associated proteins like MAP10 by creating more binding sites for functional activation. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin, inhibiting microtubule formation. When washed away, vinblastine can cause a rapid polymerization of microtubules, which may enhance the functional activation of MAP10 as it can bind to the newly formed microtubules. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, preventing its polymerization into microtubules, leading to microtubule depolymerization. The subsequent removal of colchicine can result in a surge in microtubule polymerization, which may activate MAP10, as its function is associated with microtubule stability and polymerization. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B functions similarly to paclitaxel, stabilizing microtubules and enhancing their polymerization. This can lead to an activation of MAP10 by increasing its binding to the stabilized microtubules. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin destabilizes microtubules by binding to tubulin and inhibiting its polymerization. Removal of podophyllotoxin can cause a rapid polymerization of microtubules, which may lead to the activation of MAP10, allowing it to associate with the newly polymerized microtubules. | ||||||
Laulimalide | 115268-43-4 | sc-507261 | 100 µg | $200.00 | ||
Laulimalide also promotes microtubule polymerization and stabilization, which could lead to the activation of MAP10, as MAP10 is involved in microtubule-associated functions. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
2-Methoxyestradiol binds to the colchicine binding site on beta-tubulin and promotes microtubule depolymerization. Following its removal, there can be a compensatory increase in microtubule polymerization, potentially leading to the activation of MAP10 due to its role in microtubule dynamics. | ||||||