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WWOX (WW domain containing oxidoreductase) protein is a candidate tumor suppressor consisting of two WW domains that influence protein-protein interactions, and a short chain dehydrogenase (SDR) domain, that influences sex-steroid metabolism. Modulation of the WWOX gene influences esophageal squamous cell carcinogenesis and tumorigenicity of breast cancer cell lines MDA-MB-435 and T47D. The murine homolog WOX1 localizes in the mitochondria, and contains a mitochondrial targeting sequence mapping within the SDR domain. JNK1 can physically associate with WOX1 and sequester WOX1-dependent apoptosis.
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Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps WWOX (A-5) | sc-373846 | 200 µg/ml | $316.00 | |||
WWOX (A-5): m-IgG Fc BP-HRP Kit | sc-540406 | 200 µg Ab; 10 µg BP | $354.00 | |||
WWOX (A-5): m-IgG2b BP-HRP Kit | sc-549785 | 200 µg Ab; 10 µg BP | $354.00 | |||
WWOX (A-5) peptide neutralisant | sc-373846 P | 100 µg/0.5 ml | $68.00 |