UFM1 (ubiquitin-fold modifier 1) is a ubiquitin-like protein that is conjugated to target proteins by UBA5, an E1-like activating enzyme, and Ufc1, an E2-like conjugating enzyme. Through these interactions, UFM1 conjugates to target proteins by a covalent linkage. UFSP2 (Ufm1-specific protease 2) is a 469 amino acid thiol protease that specifically cleaves UFM1 precursor and leads to exposure of its conserved C-terminal glycine, a step required prior to conjugation to target proteins. UFSP2 is also capable of releasing UFM1 from UFM1-conjugated cellular proteins. The gene encoding UFSP2 maps to human chromosome 4, which houses nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps UFSP2 (C-7) | sc-376045 | 200 µg/ml | $316.00 | |||
UFSP2 (C-7): m-IgGλ BP-HRP Kit | sc-522831 | 200 µg Ab, 40 µg BP | $354.00 |