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UCP2 Antibody (G-6) - Western Blotting - Image 379498
Anticorps UCP2 (G-6): sc-390189. Analyse par Western blot de l'expression de l'UCP2 dans les lysats de cellules entières Daudi (A) et U-698-M (B).
Anticorps UCP2 (G-6): sc-390189. Analyse par Western blot de l'expression de l'UCP2 dans les lysats de cellules entières Daudi (A) et U-698-M (B).

Anticorps UCP2 (G-6): sc-390189

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Fiches techniques
  • L'anticorps UCP2 G-6 est un monoclonal IgM κ L'Anticorps UCP2, cité dans 32 publications, fourni en 200 µg/ml
  • soulevée contre une cartographie peptidique au niveau de N-terminus de UCP2 de human d'origine
  • recommandé pour la détection de UCP2 d'origine mouse, rat et human par WB, IP, IF, IHC(P) et ELISA; également réactif avec d'autres espèces, dont et equine, canine and bovine
  • Contactez notre Service Technique (ou votre Distributeur local) pour plus d'informations pour recevoir un échantillon GRATUIT de 10 µg de UCP2 (G-6): sc-390189.
  • Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire UCP2 (G-6). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.

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Informations Recherche

VOIR ÉGALEMENT...

Anticorps supplémentaires UCP dont UCP1, UCP2 et UCP4

UCP2 Antibody (G-6) is an IgM κ mouse monoclonal UCP2 antibody (also designated Mitochondrial uncoupling protein 2 antibody, SLC25A8 antibody, or Solute carrier family 25 member 8 antibody) that detects the UCP2 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. UCP2 Antibody (G-6) is available as the non-conjugated anti-UCP2 antibody. The uncoupling protein UCP1 (formerly designated UCP) is an integral membrane protein unique to brown adipose tissue mitochondria. UCP1 forms a dimer that acts as a proton channel, which can uncouple oxidative phosphorylation by dissipating the electrochemical potential across the inner mitochondrial membrane. This process induces heat production in brown adipose tissue and is involved in regulation of body temperature and glucose metabolism. UCP2 is a structurally related protein that also uncouples mitochondrial respiration. It is more widely expressed in human and mouse tissues, including white adipose tissue and muscle, than is UCP1. UCP2 is thought to play a role in body weight regulation.

Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

Alexa Fluor® est une marque déposée de Molecular Probes Inc., OR., USA

LI-COR® et Odyssey® sont marques déposées de LI-COR Biosciences

Anticorps UCP2 (G-6) Références:

  1. Cycle des acides gras hydroperoxy médié par la protéine de découplage mitochondriale UCP2.  |  Jaburek, M., et al. 2004. J Biol Chem. 279: 53097-102. PMID: 15475368
  2. La ribonucléoprotéine nucléaire hétérogène K renforce l'expression de la protéine mitochondriale UCP2 induite par l'insuline.  |  Ostrowski, J., et al. 2004. J Biol Chem. 279: 54599-609. PMID: 15485813
  3. La surexpression du partenaire hétérodimère court rétablit la sécrétion d'insuline stimulée par le glucose dans les cellules bêta pancréatiques surexprimant l'UCP2.  |  Suh, YH., et al. 2004. J Endocrinol. 183: 133-44. PMID: 15525581
  4. Thermogenèse du tissu adipeux brun: études interdisciplinaires.  |  Himms-Hagen, J. 1990. FASEB J. 4: 2890-8. PMID: 2199286
  5. Gène humain de la protéine de découplage: structure, comparaison avec le gène du rat et affectation au bras long du chromosome 4.  |  Cassard, AM., et al. 1990. J Cell Biochem. 43: 255-64. PMID: 2380264
  6. Protéine de découplage mitochondrial de la graisse brune de la souris. Clonage moléculaire, cartographie génétique et expression de l'ARNm.  |  Jacobsson, A., et al. 1985. J Biol Chem. 260: 16250-4. PMID: 2999153
  7. Mécanismes thermogéniques dans la graisse brune.  |  Nicholls, DG. and Locke, RM. 1984. Physiol Rev. 64: 1-64. PMID: 6320232
  8. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia (Protéine de désolidarisation 2: un nouveau gène lié à l'obésité et à l'hyperinsulinémie).  |  Fleury, C., et al. 1997. Nat Genet. 15: 269-72. PMID: 9054939

Informations pour la commande

Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

Anticorps UCP2 (G-6)

sc-390189
200 µg/ml
$316.00

UCP2 (G-6) peptide neutralisant

sc-390189 P
100 µg/0.5 ml
$68.00

Hello, could you please send me the exact sequence of the N-terminal epitope which was used to generate the antibody? The reason is that I would like to try it on cells from the Xenopus frog, and therefore a good sequence conservation is required.

Posée par: Sylvain_M
Thank you for your question . The sequence is proprietary and the homology in xenopus 63%. We only warranty a specie if the homology is 95% or higher .
Répondue par: BlakeJ
Date de publication: 2023-04-24

please i want to know if his kit of ucp2 (Cat. # sc-390189 ) measure mitochondrial ucp2

Posée par: dr asmaa gomaa
Thank you for your question. This is not provided as a kit. This is a mouse monoclonal primary antibody recommended for detection of UCP2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and indirect ELISA. UCP2 is also known as Mitochondrial uncoupling protein 2. A link to the Uniprot protein page about UCP2 is provided below for your reference. https://www.uniprot.org/uniprot/P55851
Répondue par: Technical Support
Date de publication: 2024-03-13

I am interested for a free sample of the above product. (UCP2 Antibody (G-6): sc-390189)

Posée par: Mohasin
Thank you very much for your inquiry. We don't have currently a limit in the samples we can send per order, would you, or any of your colleagues, like to try any other antibody? please let me know so we make a single shipment. Please let me know the following information: - complete address for shipping - telephone, fax number and e-mail address - a contact person the products should be addressed to - catalogue number and product description Remember once you try the sample, you can write a review in our web about it, indicating all the information you think might be useful for other researchers.
Répondue par: Technical Support Europe
Date de publication: 2017-09-21

The blot for WI-38 cells shows 2 bands, 1 band nearly 80 kDa. This band is also labeled as UCP2, is it right? If yes, what ist the explanation for this band? And could it be that only the 80kDa band ist detectabel without the lower band?

Posée par: Rene 42
Thank you for your question. We have observed a higher molecular weight band ~70-80 kDa in both WI-38 and Neuro-2A whole cell lysate, as well as human liver tissue extract using this monoclonal antibody, UCP2 (G-6): sc-390189, in Western blot. UCP2 has been reported in the primary literature as a dimer at this molecular weight. As a reference, please see PMID: 11179956.
Répondue par: Technical Support
Date de publication: 2017-05-17

What is the total volume provided of UCP2 antibody (G-6)?

Posée par: AbPolly
Each vial contains 200 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
Répondue par: Technical Support 6
Date de publication: 2017-01-09
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Rated 4 de 5 de par Good!It works pretty well in liver homogenates form steatotic livers.
Date de publication: 2022-03-24
Rated 5 de 5 de par UCP2 (G-6) antibodyThis antibody is perfect for cell culture samples because of the one band that you can see in the membrane. Very clean antibody.
Date de publication: 2021-06-19
Rated 4 de 5 de par good!Bande nitide. L'anticorpo funziona bene (1:100 PBST 1%)
Date de publication: 2021-04-05
Rated 2 de 5 de par Not recommended for mouse samplesStrong non-specific bands appeared in WCE of mouse cell lines. The result was not consistent with qRT-PCR. Dilution: 1:100 in HIKARI sol. (Nacalai, Japan)
Date de publication: 2021-04-05
Rated 5 de 5 de par UCP2 antibodyVery clean and useful antibody, it works really good for Western blotting.
Date de publication: 2021-02-10
Rated 5 de 5 de par ottimo funzionamentosono rimasta soddisfatta dell' anticorpo UCP2 (G-6)
Date de publication: 2020-11-18
Rated 2 de 5 de par It doesn't work well.We used it at 1:100 dilution in BSA on human cell line. Unfortunately we had a lot of problem to detect it.
Date de publication: 2020-10-13
Rated 5 de 5 de par worked greatgood specificity and no back ground with tissue and cell 1 st *5000 2nd *5000
Date de publication: 2018-01-30
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Anticorps UCP2 (G-6) est évalué 4.0 de 5 de 27.
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