Tyro3 Antibody (9A3F2): sc-81161
- Tyro3 Antibody (9A3F2) is a mouse monoclonal mouse IgG1 κ κ provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 152-310 of Tyro3 of human origin
- recommended for detection of Tyro3 of human origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Tyro3 Antibody (9A3F2). This work is in progress.
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Tyro3 Antibody (9A3F2) is a mouse monoclonal IgG1 antibody that detects Tyro3 in human samples through applications such as western blotting (WB) and immunofluorescence (IF). Tyro3 is a member of the Axl/UFO subfamily of receptor tyrosine kinases, which play a crucial role in various biological processes, including spermatogenesis, immunoregulation, and phagocytosis. Tyro3 is primarily located on the cell membrane, where Tyro3 functions as a transmembrane signaling molecule. The extracellular domain is composed of two immunoglobulin-like domains and two fibronectin type III domains, which are essential for ligand binding and receptor dimerization. Upon binding to ligands, such as Protein S and Gas6, Tyro3 undergoes activation, leading to downstream signaling cascades that are vital for cellular responses to environmental cues. Tyro3 expression is notably abundant in tissues such as the brain, testis, and vascular systems, highlighting Tyro3′s importance in both the central nervous system and reproductive health. Additionally, Tyro3 undergoes post-translational modifications, including tyrosine phosphorylation and glycosylation, which can influence activity and interactions with other proteins. anti-Tyro3 antibody (9A3F2) serves as an invaluable tool for researchers exploring the functional dynamics of this critical receptor in various physiological and pathological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Tyro3 Antibody (9A3F2) References:
- Tyro3 receptor tyrosine kinases in the heterogeneity of apoptotic cell uptake. | Curtis, JL., et al. 2009. Front Biosci (Landmark Ed). 14: 2631-46. PMID: 19273223
- Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and colitis-associated cancer. | Rothlin, CV., et al. 2014. Inflamm Bowel Dis. 20: 1472-80. PMID: 24846720
- Tyro3 Modulates Mertk-Associated Retinal Degeneration. | Vollrath, D., et al. 2015. PLoS Genet. 11: e1005723. PMID: 26656104
- Tyro3 is a podocyte protective factor in glomerular disease. | Zhong, F., et al. 2018. JCI Insight. 3: PMID: 30429374
- New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis. | Pagani, S., et al. 2020. Dis Markers. 2020: 1614627. PMID: 32051695
- Tyro3, Axl, Mertk receptor-mediated efferocytosis and immune regulation in the tumor environment. | Zhou, L. and Matsushima, GK. 2021. Int Rev Cell Mol Biol. 361: 165-210. PMID: 34074493
- TYRO3 promotes chemoresistance via increased LC3 expression in pancreatic cancer. | Hara, K., et al. 2023. Transl Oncol. 28: 101608. PMID: 36577166
- Overexpression of TYRO3 indicates poor prognosis and induces gastric cancer progression via AKT-mTOR pathway. | Wang, J., et al. 2023. Mol Carcinog. 62: 1325-1337. PMID: 37212497
- Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis. | Gao, L., et al. 2023. Cell Commun Signal. 21: 195. PMID: 37537628
- Tyro3 promotes the maturation of glutamatergic synapses. | Miao, S., et al. 2024. Front Neurosci. 18: 1327423. PMID: 38410160
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyro3 Antibody (9A3F2) | sc-81161 | 200 µg/ml | $322.00 |