TRPC1 Antibody (E-6): sc-133076
- TRPC1 Antibody (E-6) is a mouse monoclonal IgG1 κ TRPC1 antibody, cited in 45 publications, provided at 200 µg/ml
- raised against amino acids 689-793 mapping at the C-terminus of TRPC1 of human origin
- TRPC1 Antibody (E-6) is recommended for detection of TRPC1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine, bovine and porcine
- Anti-TRPC1 Antibody (E-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TRPC1 Antibody (E-6) for WB and IHC(P) applications. These reagents are now offered in bundles with TRPC1 Antibody (E-6) (see ordering information below).
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TRPC1 Antibody (E-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects TRPC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TRPC1 (E-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The transient receptor potential cation (TRPC) channels, to which TRPC1 belongs, are integral to the regulation of calcium homeostasis in cells, playing a crucial role in store-operated calcium entry (SOCE). This process is vital for various physiological functions, including muscle contraction, neurotransmitter release, and cellular signaling. TRPC1, a 793 amino acid protein, is predominantly expressed in the fetal and adult brain, as well as in the adult heart, testis, and ovary, where TRPC1 contributes to the formation of capacitative calcium entry complexes. The interaction between inositol 1,4,5-trisphosphate receptors and TRPC1 is essential for the activation of store-mediated calcium entry, highlighting TRPC1′s importance in cellular responses to calcium depletion. Anti-TRPC1 antibody (E-6) enables researchers to gain insights into the mechanisms of calcium signaling and its implications in various biological processes and diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRPC1 Antibody (E-6) References:
- From worm to man: three subfamilies of TRP channels. | Harteneck, C., et al. 2000. Trends Neurosci. 23: 159-66. PMID: 10717675
- Transient receptor potential channels as molecular substrates of receptor-mediated cation entry. | Hofmann, T., et al. 2000. J Mol Med (Berl). 78: 14-25. PMID: 10759026
- Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets. | Rosado, JA. and Sage, SO. 2001. Biochem J. 356: 191-8. PMID: 11336651
- TRPC1 store-operated cationic channel subunit. | Beech, DJ., et al. 2003. Cell Calcium. 33: 433-40. PMID: 12765688
- TRPC1 and ORAI1 channels in colon cancer. | Villalobos, C., et al. 2019. Cell Calcium. 81: 59-66. PMID: 31203007
- TRPC1 as a negative regulator for TRPC4 and TRPC5 channels. | Kim, J., et al. 2019. Pflugers Arch. 471: 1045-1053. PMID: 31222490
- TRPC1 contributes to endotoxemia-induced myocardial dysfunction via mediating myocardial apoptosis and autophagy. | Tian, W., et al. 2022. Pharmacol Res. 181: 106262. PMID: 35598715
- Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel. | Won, J., et al. 2024. Nat Struct Mol Biol.. PMID: 39478185
- TRPC1, a human homolog of a Drosophila store-operated channel. | Wes, PD., et al. 1995. Proc Natl Acad Sci U S A. 92: 9652-6. PMID: 7568191
- Molecular cloning of a widely expressed human homologue for the Drosophila trp gene. | Zhu, X., et al. 1995. FEBS Lett. 373: 193-8. PMID: 7589464
- Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion. | Zitt, C., et al. 1996. Neuron. 16: 1189-96. PMID: 8663995
- A novel capacitative calcium entry channel expressed in excitable cells. | Philipp, S., et al. 1998. EMBO J. 17: 4274-82. PMID: 9687496
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRPC1 Antibody (E-6) | sc-133076 | 200 µg/ml | $322.00 | |||
TRPC1 Antibody (E-6): m-IgG Fc BP-HRP Bundle | sc-528741 | 200 µg Ab; 10 µg BP | $361.00 | |||
TRPC1 Antibody (E-6): m-IgGκ BP-HRP Bundle | sc-521224 | 200 µg Ab, 40 µg BP | $361.00 | |||
TRPC1 Antibody (E-6) AC | sc-133076 AC | 500 µg/ml, 25% agarose | $424.00 | |||
TRPC1 Antibody (E-6) HRP | sc-133076 HRP | 200 µg/ml | $322.00 | |||
TRPC1 Antibody (E-6) FITC | sc-133076 FITC | 200 µg/ml | $336.00 | |||
TRPC1 Antibody (E-6) PE | sc-133076 PE | 200 µg/ml | $349.00 | |||
TRPC1 Antibody (E-6) Alexa Fluor® 488 | sc-133076 AF488 | 200 µg/ml | $364.00 | |||
TRPC1 Antibody (E-6) Alexa Fluor® 546 | sc-133076 AF546 | 200 µg/ml | $364.00 | |||
TRPC1 Antibody (E-6) Alexa Fluor® 594 | sc-133076 AF594 | 200 µg/ml | $364.00 | |||
TRPC1 Antibody (E-6) Alexa Fluor® 647 | sc-133076 AF647 | 200 µg/ml | $364.00 | |||
TRPC1 Antibody (E-6) Alexa Fluor® 680 | sc-133076 AF680 | 200 µg/ml | $364.00 | |||
TRPC1 Antibody (E-6) Alexa Fluor® 790 | sc-133076 AF790 | 200 µg/ml | $364.00 |