Trk Antibody (B-3): sc-7268

Trk Antibody (B-3) is a mouse monoclonal IgG2a kappa light chain antibody engineered to recognize the Trk family of receptors, including Trk A (NTRK1), Trk B (NTRK2), and Trk C (NTRK3), across multiple species such as mouse, rat, human, bovine, and porcine. Trk mouse monoclonal antibody (B-3) specifically binds to an epitope mapping between amino acids 783-796 at the C-terminus of the Trk proteins, making it suitable for applications in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Also known as Pan Trk, TRKA/B/C, and NTRK1/2/3 antibody, anti-Trk antibody (B-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, providing flexibility for diverse experimental requirements. Trk proteins are members of the tropomyosin receptor kinase family and function as critical tyrosine kinase receptors for neurotrophic factors such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3). These interactions are essential for the development, maintenance, and function of the central and peripheral nervous systems, influencing neuronal survival, differentiation, and synaptic plasticity. Anti-Trk antibody (B-3) enables detailed study of the signaling pathways involved in neurodevelopmental processes and neurological disorders. Trk monoclonal antibody (B-3) detection of Trk A, B, and C across various species provides a versatile tool for researchers investigating the molecular mechanisms underlying neuronal growth and function.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Trk Antibody (B-3) has 72 citations in a variety of scientific publications.

Primary antibodies like Anti-Trk Antibody (B-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Trk Antibody (B-3) Specifications

Alternate Product Name: Pan Trk

Product Clone Name: B-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 783-796

Epitope Target: Trk

Epitope Species: human

Product Reactivity/Detection: Trk A, Trk B and Trk C

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 72 citations in various scientific publications

Available Conjugates/Forms for Trk Antibody (B-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred p-Trk antibody is p-Trk Antibody (E-6): sc-8058.