Date published: 2025-9-7

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Anticorps TRC8 (E-12): sc-376358

5.0(2)
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Fiches techniques
  • L'Anticorps TRC8 (E-12) est un monoclonal de souris IgG1 (chaîne légère kappa) fourni en 200 µg/ml
  • spécifique d'un épitope situé entre les acides aminés 97-133 au niveau d'une région interne de TRC8 d'origine human
  • recommandé pour la détection de TRC8 d'origine mouse, rat et human par WB, IP, IF, IHC(P) et ELISA
  • Réactifs TransCruz pour une application en ChIP (sc-376358 X, 200 µg/0.1 ml)
  • m-IgG Fc BP-HRP et m-IgG1 BP-HRP sont les réactifs secondaires recommandés pour la détection de l'anticorps TRC8 (E-12) pour des applications de WB and IHC(P). Ces réactifs sont maintenant proposés en kit avec l'anticorps TRC8 (E-12) (voir Informations pour la commande ci-dessous).

    ACCÈS RAPIDE AUX LIENS

    VOIR ÉGALEMENT...

    TRC8 (translocation in renal carcinoma on chromosome 8), also known as RNF139 (ring finger protein 139), RCA1 or HRCA1 (hereditary renal cancer associated 1), is a multi-pass membrane protein that is predominantly expressed in testis, adrenal gland and placenta and is expressed at lower levels in liver, skeletal muscle, pancreas, kidney, brain, heart and lung. Localizing to the endoplasmic reticulum (ER), TRC8 contains ten transmembrane segments, a sterol-sensing domain and one RING-type zinc finger and may function as a ubiquitin ligase and signaling receptor. TRC8 physically interacts with VHL (Von Hippel Lindau disease tumor suppressor), and the inhibition of either of these proteins leads to the same ventral midline defect. Disruption of the TRC8 gene, caused by the 3;8 chromosomal translocation, is associated with hereditary renal cell carcinoma (RCC), suggesting that TRC8 is a potential tumor suppressor for RCC. Further supporting its role as a tumor suppressor, TRC8 mediates the induction of G2/M phase arrest, increased apoptosis and decreased DNA synthesis.

    Pour la Recherche Uniquement. Non destiné à un usage diagnostique ou thérapeutique.

    Informations pour la commande

    Nom du produitRef. CatalogueCOND.Prix HTQTÉFavoris

    Anticorps TRC8 (E-12)

    sc-376358
    200 µg/ml
    $316.00

    TRC8 (E-12): m-IgG Fc BP-HRP Kit

    sc-540552
    200 µg Ab; 10 µg BP
    $354.00

    TRC8 (E-12): m-IgG1 BP-HRP Kit

    sc-542200
    200 µg Ab; 20 µg BP
    $354.00

    TRC8 (E-12) peptide neutralisant

    sc-376358 P
    100 µg/0.5 ml
    $68.00

    Anticorps TRC8 (E-12) X

    sc-376358 X
    200 µg/0.1 ml
    $316.00

    What application is the blocking peptide sc-376358 P appropriate for?

    Posée par: TinTin
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Répondue par: Technical Support
    Date de publication: 2017-02-27
    • y_2025, m_8, d_29, h_8CST
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    Rated 5 de 5 de par Produced excellent immunoperoxidase cytoplasmicProduced excellent immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human testis tissue. -SCBT QC
    Date de publication: 2015-03-07
    Rated 5 de 5 de par Produced positive Western Blot data of TRC8Produced positive Western Blot data of TRC8 expression in non-transfected and human TRC8 transfected 293T whole cell lysates. -SCBT QC
    Date de publication: 2014-02-01
    • y_2025, m_8, d_29, h_8
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    Anticorps TRC8 (E-12) est évalué 5.0 de 5 de 2.
    • y_2025, m_8, d_29, h_8
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