TOX (Thymocyte selection-associated high mobility group (HMG) box protein) is a 526 amino acid nuclear protein that is a member of the HMG box family of DNA-binding proteins and likely plays a role in the regulation of T-cell development. Expression of TOX is upregulated by pre-T cell receptor (pre-TCR) and TCR activation in immature thymocytes, but not by TCR activation in mature thymocytes. CD4 T cells fail to develop in TOX-deficient mice, however functional CD8(+) T cells still develop, suggesting that TOX-dependent transition to the CD4(+)CD8 stage is required for development of class II major histocompatibility complex-specific T cells. Calcineurin activation events and CD8 lineage commitment seem to be linked due to evidence that up-regulation of TOX in double positive thymocytes is calcineurin dependent.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TOX (G-5) | sc-374136 | 200 µg/ml | $316.00 | |||
TOX (G-5) peptide neutralisant | sc-374136 P | 100 µg/0.5 ml | $68.00 |