Anticorps TLE1 (C-7): sc-137097
- L'Anticorps TLE1 (C-7) est un monoclonal de souris IgG1 κ, cité dans 2 publications, fourni en 200 µg/ml
- dirigé contre les acides aminés 200-350 de TLE1 d'origine mouse
- recommandé pour la détection de TLE1 d'origine mouse, rat et human par WB, IP, IF et ELISA
- Réactifs TransCruz pour une application en ChIP (sc-137097 X, 200 µg/0.1 ml)
- Voir TLE1 (F-4): sc-137098 pour d'autres anticorps conjugués TLE1, dont AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 et 790.
- 1 BP-HRP">m-IgG1 BP-HRP est le réactif de détection secondaire préféré pour l'anticorps TLE1 (C-7) pour les applications WB. Ce réactif est désormais proposé en association avec l'anticorps TLE1 (C-7)(voir les informations relatives à la commande ci-dessous).
The Notch signaling pathway controls cellular interactions important for the specification of a variety of fates in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. Groucho is a transcriptional repressor that plays a key role in neurogenesis, segmentation and sex determination. TLEs associate with chromatin in live cells and specifically with Histone H3, but not with other core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward a terminally differentiated state, suggesting a role during epithelial differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervical squamous metaplasias and carcinomas, while TLE4 is most highly expressed in the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced transactivation of the CSF1 receptor. In early stages of cell differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In later stages, TLE2 and TLE4 are upregulated, and expression of TLE1 decreases.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TLE1 (C-7) | sc-137097 | 200 µg/ml | $316.00 | |||
TLE1 (C-7): m-IgG1 BP-HRP Kit | sc-542649 | 200 µg Ab; 20 µg BP | $354.00 | |||
Anticorps TLE1 (C-7) X | sc-137097 X | 200 µg/0.1 ml | $316.00 |